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Original Paper

Pregnancy in Women with Epilepsy

Laskowska M. · Leszczyńska-Gorzelak B. · Oleszczuk J.

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Department of Obstetrics and Perinatology, University School of Medicine, Lublin, Poland

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Gynecol Obstet Invest 2001;51:99–102

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 21, 2001
Issue release date: February 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

The aim of this study was to analyze the outcome of pregnancy and delivery in epileptic women. A retrospective review of the 41 pregnant women with epilepsy who delivered in the Department of Obstetrics and Perinatology of the University School of Medicine in Lublin over 7 years (1993–1999) was carried out. Women with epilepsy had more pregnancy complications including premature labor, anemia, hypertension, vaginal bleeding, urinary tract infection, nausea and vomiting. An increased risk of congenital malformations and intrauterine fetal growth retardation was observed. Women with epilepsy require more extensive pregnancy planning including neurologic and preconceptional care.

© 2001 S. Karger AG, Basel


References

  1. Swartjes JM, van Geijn HP: Pregnancy and epilepsy. Eur J Obstet Gynecol Reprod Biol 1998;79:3–11.
  2. Lindhout D, Omtzigt JG: Teratogenic effects of antiepileptic drugs: Implications for the management of epilepsy in women of child-bearing age. Epilepsia 1994;35 (suppl 4):19–28.
  3. Olafsson E, Hallgrimsson JT, Hauser WA, Ludvigsson P, Gudmundsson G: Pregnancies of women with epilepsy: A population-based study in Iceland. Epilepsia 1998;39:887–892.
    External Resources
  4. Schupf N, Ottman R: Reproduction among individuals with idiopathic/cryptogenic epilepsy: Risk factors for spontaneous abortion. Epilepsia 1997;38:824–829.
  5. Zahn C: Neurologic care of pregnant women with epilepsy. Epilepsia 1998;39 (suppl 8):26–31.
  6. Ohba T, Yoshimura T, Ohyama K, Okamura H: A case of fetal intracranial bleeding complicated by hydrocephalus in a women with frequent epileptic seizures. J Matern Fetal Investig 1998;8:98–100.
    External Resources
  7. Tomson T, Danielsson BR, Winbladh B: Epilepsy and pregnancy. Balancing between risks to the mother and child. Lakartidningen 1997;94:2827–2832, 2835.
  8. Eller DP, Patterson CA, Webb GW: Maternal and fetal implications of anticonvulsive therapy during pregnancy. Obstet Gynecol Clin North Am 1997;24:523–534.
  9. Delgado-Escueta AV, Janz D: Consensus guidelines: Preconception counseling, management, and care of the pregnant woman with epilepsy. Neurology 1992;42(suppl 5):149–160.
  10. Dansky LV, Rosenblatt DS, Andermann E: Mechanisms of teratogenesis: Folic acid and antiepileptic therapy. Neurology 1992;42(suppl 5):32–42.
  11. Omtzigt JG, Nau H, Los FJ, Pijpers L, Lindhout D: The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: Effect of dose, co-medication, and the presence of spina bifida. Eur J Clin Pharmacol 1992;43:381–388.
    External Resources
  12. Bradai R, Robert E: Prenatal ultrasonographic diagnosis in the epileptic mother on valproic acid. Retrospective study of 161 cases in the central eastern France register of congenital malformations. J Gynecol Obstet Biol Reprod Paris 1998;27:413–419.
  13. Samrén EB, van Duijn CM, Koch S, Hiilesmaa VK, Klepel H, Bardy AH, Mannagetta GB, Deichl AW, Gaily E, Granström ML, Meinardi H, Grobbee DE, Hofman A, Janz D, Lindhout D: Maternal use of antiepileptic drugs and the risk of major congenital malformations: A joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia 1997;39:981–990.
  14. Bennett GD, Lau F, Calvin JA, Finnell RH: Phenytoin-induced teratogenesis: A molecular basis for the observed developmental delay during neurulation. Epilepsia 1997;38:415–423.
    External Resources
  15. Crawford P: Epilepsy and pregnancy: Good management reduces the risks. Prof Care Mother Child 1997;7:17–18.
    External Resources
  16. Baggot PJ, Kalamarides JA, Shoemaker JD: Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: A case report. Epilepsia 1999;40:512–515.
    External Resources
  17. Bruni J: Women’s issues in the treatment of epilepsy. Can J Neurol Sci 1998;25:S19–S23.
    External Resources
  18. El-Sayed YY: Obstetric and gynecologic care of women with epilepsy. Epilepsia 1998;39(suppl 8):17–25.
  19. Rochester JA, Kirchner JT: Epilepsy in pregnancy. Am Fam Physician 1997;56:1631–1636.
    External Resources
  20. Sabers A, aRogvi-Hansen B, Dam M, Fischer-Rasmussen W, Gram L, Hansen M, Moller A, Winkel H: Pregnancy and epilepsy: A retrospective study of 151 pregnancies. Acta Neurol Scand 1998;97:164–170.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: February 21, 2001
Issue release date: February 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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