Influence of Preeclampsia or Maternal Intake of Omega–3 Fatty Acids on the Vasoactive Effect of Prostaglandin F-Two-Alpha in Human Umbilical ArteriesHaugen G.a · Helland I.b
Departments of aObstetrics and Gynecology and bPediatric Research, National Hospital, University of Oslo, Norway
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The vasoactive effect of prostaglandin F2α (PGF2α) was studied in in vitro perfused human umbilical arteries following maternal dietary supplementation with ω–3 fatty acids or in pregnancies complicated by a moderate degree of preeclampsia. In most preparations PGF2α induced a biphasic pressure response with a transient dilatation followed by a constrictory response. The pressure increase was significant in both groups, but no significant differences in the constrictory response or in the proportions of preparations displaying dilatatory responses were observed when compared to appropriate control groups. In conclusion, neither preeclampsia nor dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF2α in umbilical cord arteries.
© 2001 S. Karger AG, Basel
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