Wide Distribution of Laminin-5 γ2 Chain in Basement Membranes of Various Human TissuesMizushima H.a · Koshikawa N.a · Moriyama K.a · Takamura H.a · Nagashima Y.b · Hirahara F.c · Miyazaki K.a
a Division of Cell Biology, Kihara Institute for Biological Research, Yokohama CityUniversity, and Departments of b Pathology and c Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan
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Laminin 5 (LN5), a heterotrimer of laminin α3, β3, and γ2 chains, is a laminin isoform which strongly promotes adhesion, migration, and scattering of cells through binding to integrins α3β1, α6β1 and α6β4. To get an insight into the physiological functions of LN5, we prepared a mouse monoclonal antibody to human laminin γ2 chain and used it for immunohistochemical analysis of laminin γ2 chain in normal human tissues. The basement membranes of various epithelial tissues, such as the skin, lung, small intestine, stomach, kidney and prostate, were immunostained with the anti-laminin γ2 chain monoclonal antibody. In addition, the basement membrane of the surface germinal epithelium in the ovary was also positive for laminin γ2 chain. These results suggest general roles of LN5 in the anchorage of various types of epithelial cells to the underlying basement membrane and in the expression of their cellular functions. Moreover, deposition of laminin γ2 chain around small arteries and veins was observed in the thymus and spleen. This lymphatic organ-specific expression of vascular LN5 might provide a novel function of LN5 in immune responses.
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