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Intracellular Signaling Pathways in Human Eosinophil Activation: Role of a β2 Integrin, αMβ2

Kato M.a · Kimura H.b · Tachibana A.a · Motegi Y.a · Tokuyama K.a · Kita H.c · Morikawa A.a

Author affiliations

aDepartment of Pediatrics, Gunma University School of Medicine, bGunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan; cDepartment of Immunology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn., USA

Related Articles for ""

Int Arch Allergy Immunol 1999;120(suppl 1):51–53

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 01, 1999
Issue release date: September 1999

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Cellular adhesion is crucial roles for eosinophil effector functions such as degranulation. Here, we focused on the role of a β2 integrin, αMβ2, in intracellular signaling pathways of human eosinophil activation. We found that the ligation of αMβ2 triggers the activation of an intracellular signaling cascade, including protein tyrosine phosphorylation and phosphoinositide turnover, and subsequent cellular degranulation in human eosinophils. These signaling events may play important roles in adhesion-dependent cellular functions of eosinophils.


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 01, 1999
Issue release date: September 1999

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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