Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Determination of Phylloquinone and Menaquinones in Food

Effect of Food Matrix on Circulating Vitamin K Concentrations

Schurgers L.J. · Vermeer C.

Author affiliations

Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands

Related Articles for ""

Haemostasis 2000;30:298–307

Do you have an account?

Login Information





Contact Information











I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information











I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

For eJournal Archive and eJournal Backfiles information please contact service@karger.com

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 11, 2001
Issue release date: April 2001

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT

Abstract

Fluctuations in international normalized ratio values are often ascribed to dietary changes in vitamin K intake. Here we present a database with vitamin K1 and K2 contents of a wide variety of food items. K1 was mainly present in green vegetables and plant margarins, K2 in meat, liver, butter, egg yolk, natto, cheese and curd cheese. To investigate the effect of the food matrix on vitamin K bioavailability, 6 healthy male volunteers consumed either a detergent-solubilized K1 (3.5 µmol) or a meal consisting 400 g of spinach (3.5 µmol K1) and 200 g of natto (3.1 µmol K2). The absorption of pure K1 was faster than that of food-bound K vitamins (serum peak values at 4 h vs. 6 h after ingestion). Moreover, circulating K2 concentrations after the consumption of natto were about 10 times higher than those of K1 after eating spinach. It is concluded that the contribution of K2 vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.

© 2001 S. Karger AG, Basel


References

  1. Furie B, Furie BC: Molecular and cellular biology of blood coagulation. N Engl J Med 1992;326:800–806.
  2. Shearer MJ: Vitamin K. Lancet 1995;345:229–234.
  3. Vermeer C: Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J 1990;266:625–636.
  4. Shearer MJ: Vitamin K metabolism and nutriture. Blood Rev 1992;6:92–104.
  5. Shearer MJ, Bach A, Kohlmeier M: Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr 1996;126:1181S–1186S.
  6. Schurgers LJ, Geleijnse JM, Grobbee DE, Pols HAP, Hofman A, Witteman JCM, Vermeer C: Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. J Nutr Environ Med 1999;9:115–122.
  7. Martius C, Esser HO: Über die Konstitution des im Tierkörper aus Methylnaphthochinon gebildeten K-Vitamines. Biochem Z 1958;331:S1–S9.
  8. Dialameh GH, Taggart WV, Matschiner JT, Olson RE: Isolation and characterization of menaquinone-4 as a product of menadione metabolism in chicks and rats. Int J Vitam Nutr Res 1971;41:391–400.
    External Resources
  9. Ronden JE, Drittij-Reijnders MJ, Vermeer C, Thijssen HHW: Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Biochim Biophys Acta 1998;1379:16–22.
  10. Thijssen HHW, Drittij-Reijnders MJ, Fischer MAJG: Phylloquinone and menaquinone-4 distribution in rats: Synthesis rather than uptake determines menaquinone-4 organ concentrations. J Nutr 1996;126:537–543.
  11. Conly JM, Stein K, Worobetz L, Rutledge-Harding S: The contribution of vitamin K2 (menaquinones) produced by intestinal microflora to human nutritional requirements for vitamin K. Am J Gastroenterol 1994;89:915–923.
  12. Vermeer C, Hamulyák K: Pathophysiology of vitamin K deficiency and oral anticoagulants. Thromb Haemost 1991;66:153–159.
  13. Duxbury B: Therapeutic control of anticoagulant treatment. Br Med J 1982;284:702–704.
  14. Kumar S, Haigh JR, Rhodes LE, Peaker S, Davies JA, Roberts BE, Feely MP: Poor compliance is a major factor in unstable outpatient control of anticoagulant therapy. Thromb Haemost 1989;62:729–732.
  15. James AH, Britt RP, Raskino CL, Thompson SG: Factors affecting the maintenance dose of warfarin. J Clin Pathol 1992;45:704–706.
  16. Harris JE: Interaction of dietary factors with oral anticoagulants: Review and applications. J Am Diet Assoc 1995;95:580–584.
  17. Beyth RJ, Landefeld CS: Anticoagulants in older patients. A safety perspective. Drugs Aging 1995;6:45–54.
    External Resources
  18. Wynne H, Cope L, Kelly P, Whittingham T, Edwards C, Kamali F: The influence of age, liver size and enantiomer concentrations on warfarin requirements. Br J Clin Pharmacol 1995;40:203–207.
  19. Qureshi GD, Reinders TP, Swint JJ, Slate MB: Acquired warfarin resistance and weight-reducing diet. Arch Intern Med 1981;141:507–509.
  20. Kempin SJ: Warfarin resistance caused by broccoli. N Engl J Med 1983;308:1229–1230.
  21. Karlson B, Leijd B, Hellstrom K: On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. Acta Med Scand 1986;220:347–350.
  22. Kalra PA, Cooklin M, Wood G, O’Shea GM, Holmes AM: Dietary modification as cause of anticoagulation instability. Lancet 1988;ii:803.
  23. Pedersen FM, Hamberg O, Hess K, Ovesen L: The effect of dietary vitamin K on warfarin-induced anticoagulation. J Intern Med 1991;229:517–520.
  24. Garber AK, Binkley NC, Krueger DC, Suttie JW: Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. J Nutr 1999;129:1201–1203.
  25. Gijsbers BLMG, Jie KS, Vermeer C: Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr 1996;76:223–229.
  26. Shearer MJ: The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc 1997;56:915–937.
  27. Ferland G, Sadowski JA: Vitamin K1 (phylloquinone) content of edible oils: Effects of heating and light exposure. J Agric Food Chem 1992;40:1869–1873.
  28. Booth SL, Sadowski JA, Weihrauch JL, Ferland G: Vitamin K1 (phylloquinone) content of foods: A provisional table. J Food Comp Anal 1993;6:109–120.
  29. Bolton-Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJ: Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr 2000;83:389–399.
  30. Vermeer C, Knapen HMJ, Schurgers LJ: Vitamin K and metabolic bone disease. J Clin Pathol 1998;51:424–426.
  31. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997;386:78–81.
  32. Will BH, Suttie JW: Comparative metabolism of phylloquinone and menaquinone-9 in rat liver. J Nutr 1992;122:953–958.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 11, 2001
Issue release date: April 2001

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 2

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: https://www.karger.com/PHT


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.