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Original Paper

Urinary Retinol-Binding Protein as a Prognostic Marker in Glomerulopathies

Mastroianni Kirsztajn G. · Nishida S.K. · Silva M.S. · Ajzen H. · Moura L.A. · Pereira A.B.

Author affiliations

Division of Nephrology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil

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Nephron 2002;90:424–431

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 08, 2002
Issue release date: April 2002

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Tubulointerstitial involvement seems to have a decisive influence on the progression of glomerular diseases. We have prospectively evaluated the levels of urinary retinol-binding protein (urRBP), a marker of proximal tubular dysfunction, in patients with different glomerulopathies (GPs) and correlated these levels with disease progression. By studying 238 patients with GPs, we found that urRBP tend to be lower in minimal change disease, glomerular hematuria and poststreptococcal glomerulonephritis as compared to focal segmental glomerulosclerosis, membranous nephropathy and membranoproliferative glomerulonephritis. By following 149 patients for up to 10 years, we have concluded that high levels of urRBP can identify patients who will progress with loss of renal function (defined as doubling of serum creatinine level) and that a urRBP level >1 mg/l was an efficient and independent indicator of poor prognosis as shown by multivariate analysis. This prediction was possible at a time when serum creatinine and creatinine clearance were still in the normal range. Our data suggest that this laboratory test adds important clinical information to the follow-up of GPs.

© 2002 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 08, 2002
Issue release date: April 2002

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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