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Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in Taiwan

Liou Y.-J.a · Tsai S.-J.a,b · Hong C.-J.a,b · Wang Y.-C.c · Lai I.-C.a

Author affiliations

aDepartment of Psychiatry, Veterans General Hospital-Taipei, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, and cSection of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, ROC

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Neuropsychobiology 2001;43:11–14

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: January 08, 2001
Issue release date: January 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine. This study examined the relationship between a functional polymorphism (val158met) of the COMT gene, schizophrenia and its associated behaviors. One hundred and ninety-eight Chinese schizophrenic patients and 188 controls were genotyped by polymerase chain reaction restriction fragment length polymorphism. Of the schizophrenic patients, 72 had a history of violence and 62 had a history of suicide attempts. The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide. However, our results showed a significant difference in age at disease onset among different genotypes (F = 5.501, p = 0.005).

© 2001 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels)  /  Original Paper

Published online: January 08, 2001
Issue release date: January 2001

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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