Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Association Analysis of a Functional Catechol-O-Methyltransferase Gene Polymorphism in Schizophrenic Patients in TaiwanLiou Y.-J.a · Tsai S.-J.a,b · Hong C.-J.a,b · Wang Y.-C.c · Lai I.-C.a
aDepartment of Psychiatry, Veterans General Hospital-Taipei, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, and cSection of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, ROC
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine. This study examined the relationship between a functional polymorphism (val158met) of the COMT gene, schizophrenia and its associated behaviors. One hundred and ninety-eight Chinese schizophrenic patients and 188 controls were genotyped by polymerase chain reaction restriction fragment length polymorphism. Of the schizophrenic patients, 72 had a history of violence and 62 had a history of suicide attempts. The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide. However, our results showed a significant difference in age at disease onset among different genotypes (F = 5.501, p = 0.005).
© 2001 S. Karger AG, Basel
Carlsson A: The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1998;1:179–186.
Weinshilboum RM, Raymond FA: Inheritance of low erythrocyte catechol-O-methyltransferase activity in man. Am J Hum Genet 1977;29:216–218.
Spielman RS, Weinshilboum RM: Genetics of red cell COMT activity: Analysis of thermal stability and family data. Am J Hum Genet 1981;10:279–290.
- Lachman HM, Papolos DF, Satio T, Yu YM, Szumlanski CL, Weinshilboum RM: Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243–250.
- Lotta T, Vidgren J, Tilgmann C, Umanen I, Melen K, Julkunen I, Taskinen J: Kinetics of human soluble and membrane bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995;34:4202–4210.
- Floderus Y, Ross S, Wetterberg L: Erythrocyte catechol-O-methyltransferase activity in related families with schizophrenia. Clin Genet 1981;19:379–385.
- Shprinzten RJ, Goldberg R, Golding-Kushner KJ, Marion RW: Late-onset psychosis in the velo-cardio-facial syndrome. Am J Med Genet 1992;42:141–142.
- Pulver AE, Nastade G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyneric MA, Morrow B, Karayiorgou M, Antonarakis SE, Housman D, Kucherlapati R: Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 1994;182:476–478.
- Kelly D, Goldberg R, Wilson D, Lindsay E, Carey A, Goodship J, Burn J, Cross I, Shprintzen RJ, Scambler PJ: Confirmation that the velo-cardio-facial syndrome is associated with haplo-insufficiency of genes at chromosome 22q11. Am J Med Genet 1993;45:308–312.
- Lasseter VK, Pulver AE, Wolyniec PS, Nestadt G, Meyers D, Karayiorgou M, Housman D, Antonarakis S, Kazazian H, Kasch L, Babb R, Kimberland M, Childs B: Follow-up report to potential linkage for schizophrenia on chromosome 22q. Am J Med Genet 1995;60:172–173.
- Schizophrenia Collaborative Linkage Group: A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for long arm of chromosome 22. Am J Med Genet 1996;67:40–45.
- Grossman MH, Emanual BS, Budarf ML: Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1–q11.2. Genomics 1992;12:822–825.
- Strous RD, Bark Nigel, Parsia SS, Volavka J, Lachman HM: Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997;69:71–77.
- Lachman HM, Nolan KA, Mohr P, Satio T, Volavka J: Association between catechol-O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 1998;155:835–837.
- Vandenbergh DJ, Rodriguez LA, Miller IT, Uhl GR, Lachman HM: High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am J Med Genet 1997;74:439–442.
- Ohara K, Nagai M, Suzuki Y, Ohara K: Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression. Neuroreport 1998;9:1305–1308.
- Tsai SJ, Liu HC, Liu TY, Wang YC, Hong CJ: Association analysis of the serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior. Neurosci Lett 1999;271:135–137.
- McNiel DE, Binder RL: Biochemical aspects of aggression in man. J Nerv Ment Dis 1986;174:107–111.
- Daniels JK, Williams NM, Williams J, Jones LA, Cardro AG, Murphy KC, Spurlock G, Riley B, Scambler P, Asherson P, McGuffin P, Owen MS: No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity. Am J Psychiatry 1996;153:268–270.
- Strous RD, Bark N, Woerner M, Lachman HM: Lack of association of a functional catechol-D-methyltransferase gene polymorphism in schizophrenia. Biol Psychiatry 1997;41:493–495.
- Karayiorgou M, Gogos JA, Galke BL, Wolyniec PS, Nestadt G, Antonarakis SE, Kazazian HH, Housman DE, Pulver AE: Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility. Biol Psychiatry 1998;43:425–431.
- Chen CH, Lee YU, Wei FC, Koong FJ, Hwu HG, Hsiao KJ: Association study of NlaIII and MspI genetic polymorphisms of catechol-O-methyltransferase gene and susceptibility to schizophrenia. Biol Psychiatry 1997;41:985–987.
- Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine level and behavior. Proc Natl Acad Sci USA 1998;95:9991–9996.
- Lachman HM, Kelsoe J, Moreno L, Katz S, Papolos DF: Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar disorder. Psychiatr Genet 1997;7:13–17.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.