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Pharmacoelectroencephalography. Main Editor: W.M. Herrmann (Berlin) / Original Paper

EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in Schizophrenia

Danos P.a,c · Guich S.b · Abel L.b · Buchsbaum M.S.a

Author affiliations

aNeuroscience PET Laboratory, Mount Sinai Medical Center, New York, N.Y., and bBrain Imaging Center, University of California, Irvine, Calif., USA; cDepartment of Psychiatry, University of Magdeburg, Germany

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Neuropsychobiology 2001;43:265–272

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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography. Main Editor: W.M. Herrmann (Berlin)  /  Original Paper

Published online: May 02, 2001
Issue release date: May 2001

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Positron emission tomography with uptake of [18F]fluorodeoxyglucose (FDG) and quantitative EEG were simultaneously performed in 18 medication-free patients with schizophrenia and in 13 normal volunteers. Subjects performed the Continuous Performance Task (CPT) during FDG uptake. Correlations were calculated between alpha power during the CPT and glucose metabolic rate (GMR) in thalamic regions and between alpha power during the CPT and GMR in occipital cortices. Regression analyses were used to describe the prediction of GMR in the occipital cortices and in the thalamic regions of occipital alpha power. In normal controls, we found (1) significant negative correlations between absolute alpha power and GMR in the left occipital cortex, (2) significant positive correlations between normalized alpha power and GMR in the right and left lateral thalamus and (3) combined effects of GMR in the thalamic regions and the occipital cortices on alpha power, which accounted for 98% of the variance of alpha power. In patients with schizophrenia, we found no significant correlations between alpha power and GMR in the occipital cortices or between alpha power and GMR in the thalamic regions. Correlation coefficients between absolute alpha power and GMR in the left occipital cortex and between normalized alpha power and GMR in the left lateral thalamus were significantly different in normal subjects compared to schizophrenic patients. The present findings provide evidence for involvement of the thalamus in the generation of alpha rhythm in humans. Furthermore, the present results suggest differences in thalamocortical circuits between normal controls and schizophrenic subjects.

© 2001 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Pharmacoelectroencephalography. Main Editor: W.M. Herrmann (Berlin)  /  Original Paper

Published online: May 02, 2001
Issue release date: May 2001

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS


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