Pharmacoelectroencephalography. Main Editor: W.M. Herrmann (Berlin) / Original Paper
EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in SchizophreniaDanos P.a,c · Guich S.b · Abel L.b · Buchsbaum M.S.a
aNeuroscience PET Laboratory, Mount Sinai Medical Center, New York, N.Y., and bBrain Imaging Center, University of California, Irvine, Calif., USA; cDepartment of Psychiatry, University of Magdeburg, Germany
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Positron emission tomography with uptake of [18F]fluorodeoxyglucose (FDG) and quantitative EEG were simultaneously performed in 18 medication-free patients with schizophrenia and in 13 normal volunteers. Subjects performed the Continuous Performance Task (CPT) during FDG uptake. Correlations were calculated between alpha power during the CPT and glucose metabolic rate (GMR) in thalamic regions and between alpha power during the CPT and GMR in occipital cortices. Regression analyses were used to describe the prediction of GMR in the occipital cortices and in the thalamic regions of occipital alpha power. In normal controls, we found (1) significant negative correlations between absolute alpha power and GMR in the left occipital cortex, (2) significant positive correlations between normalized alpha power and GMR in the right and left lateral thalamus and (3) combined effects of GMR in the thalamic regions and the occipital cortices on alpha power, which accounted for 98% of the variance of alpha power. In patients with schizophrenia, we found no significant correlations between alpha power and GMR in the occipital cortices or between alpha power and GMR in the thalamic regions. Correlation coefficients between absolute alpha power and GMR in the left occipital cortex and between normalized alpha power and GMR in the left lateral thalamus were significantly different in normal subjects compared to schizophrenic patients. The present findings provide evidence for involvement of the thalamus in the generation of alpha rhythm in humans. Furthermore, the present results suggest differences in thalamocortical circuits between normal controls and schizophrenic subjects.
© 2001 S. Karger AG, Basel
Berger H: Über das Elektroenkephalogramm des Menschen. I. Arch Psychiatr Nervenkr 1929;87:527–570.
- Steriade M, Llinás RR: The functional states of the thalamus and the associated neuronal interplay. Physiol Rev 1988;68:649–742.
- Steriade M, Gloor P, Llinás RR, Lopes da Silva FH, Mesulam MM: Basic mechanisms of cerebral rhythmic activities. Electroenceph Clin Neurophysiol 1990;76:481–508.
Andersen P, Andersson SA: Physiological Basis of the Alpha Rhythm. New York, Appleton-Century-Crofts, 1968.
- Buzsaki G: The thalamic clock: Emergent network properties. Neuroscience 1991;41:351–364.
Lopes da Silva FH, Vos JE, Mooibroek J, Van Rotterdam A: Partial coherence analysis of thalamic and cortical alpha rhythms in dog – A contribution towards a general model of the cortical organization of rhythmic activity; in Pfurtscheller G, Buser P, Lopes da Silva FH (eds): Rhythmic EEG Activities and Cortical Functioning. Amsterdam, Elsevier/North-Holland Biomedical Press, 1980, pp 33–59.
- Markand ON: Alpha rythms. J Clin Neurophysiology 1990;7:163–189.
Buchsbaum MS, Cappelletti J, Coppola R, Regal F, King AC, van Kammen DP: New methods to determine the CNS effects of antigeriatric compounds: EEG topography and glucose use. Drug Dev Res 1982;2:489–496.
- Leuchter AF, Uijtdehaage SHJ, Cook IA, O’Hara R, Mandelkern M: Relationship between brain electrical activity and cortical perfusion in normal subjects. Psychiatry Res 1999;90:125–140.
- Sadato N, Nakamura S, Oohashi T, Nishina E, Fuwamoto Y, Waki A, Yonekura Y: Neural networks for generation and suppression of alpha rhythm: A PET study. Neuroreport 1998;9:893–897.
- Bartlett E, Brodie J, Wolf A, Christman D, Laska E, Meissner M: Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab 1988;8:502–512.
- Etevenon P: Intra and inter-hemispheric changes in alpha intensities in EEGs of schizophrenic patients versus matched controls. Biol Psychol 1984;19:247–256.
- Gaebel W, Ulrich G: Topographical distribution of absolute alpha-power in the EEG and psychopathology in schizophrenic outpatients. Acta Psychiatr Scand 1988;77:390–397.
- Merrin EL, Floyd TC: Negative symptoms and EEG alpha activity in schizophrenic patients. Schizophr Res 1992;8:11–20.
Merrin EL, Floyd TC: Clinical symptoms of schizophrenia affect reference-independent measures of task-induced EEG alpha asymmetry. Psychiary Res 1997;74:47–62.
- Lesch A, Bogerts B: The diencephalon in schizophrenia: Evidence of reduced thickness of the periventricular grey matter. Eur Arch Psychiatr Neurol Sci 1984;234:212–219.
- Pakkenberg B: Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 1990;47:1023–1028.
- Pakkenberg B: The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics. Schizophr Res 1992;7:95–100.
- Danos P, Baumann B, Bernstein HG, Franz M, Stauch R, Northoff G, Krell D, Falkai P, Bogerts B: Schizophrenia and anteroventral thalamic nucleus: Selective decrease of parvalbumin-immunoreactive thalamocortical neurons. Psychiatry Res 1998;82:1–10.
- Andreasen NC, Arndt S, Swayze V II, Cizadlo T, Flaum M, O’Leary D, Ehrhard JC, Yuh WT: Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 1994;266:294–298.
- Gur RE, Maany V, Mosley PD, Swanson C, Bilker W, Gur RC: Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am J Psychiatry 1998;155:1711–1717.
- Hazlett EA, Buchsbaum MS, Byne W, Wei TC, Spiegel-Cohen J, Geneve C, Kinderlehrer R, Haznedar MM, Shihabuddin L, Siever LJ: Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum. Am J Psychiatry 1999;156:1190–1199.
- Dasari M, Friedman L, Jesberger J, Stuve TA, Findling RL, Swales TP, Schulz SC: A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls. Psychiatry Res 1999;91:155–162.
- Siegel BV Jr, Buchsbaum MS, Bunney WE Jr, Gottschalk LA, Haier RJ, Lohr JB, Lottenberg S, Najafi A, Nuechterlein KH, Potkin SG, Wu JC: Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am J Psychiatry 1993;150:1325–1336.
- Buchsbaum MS, Someya T, Teng CY, Abel L, Chin S, Najafi A, Haier RJ, Wu J, Bunney WE Jr: PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am J Psychiatry 1996;153:191–199.
- Heimberg C, Komoroski RA, Lawson WB, Cardwell D, Karson CN: Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of drug effect. Psychiatry Res 1998;83:105–115.
- Rodriguez VM, Andree RM, Castejon MJ, Zamora ML, Alvaro PC, Delgado JL, Vila FJ: Fronto-striato-thalamic perfusion and clozapine response in treatment-refractory schizophrenic patients. A 99mTc-HMPAO study. Psychiatry Res 1997;76:51–61.
- Min SK, An SK, Jon DI, Lee JD: Positive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: A high-resolution SPECT study. Psychiatry Res 1999;90:159–168.
- Larson CL, Davidson RJ, Abercrombie HC, Ward RT, Schaefer SM, Jackson DC, Holden JE, Perlman SB: Relations between PET-derived measures of thalamic glucose metabolism and EEG alpha power. Psychophysiology 1998;35:162–169.
- Lindgreem KA, Larson CL, Schaefer SM, Abercrombie HC, Ward RT, Oakes TR, Holden JE, Perlman SB, Benca RM, Davidson RJ: Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients. Biol Psychiatry 1999;45:943–952.
- Buchsbaum M, Haier R, Potkin S, Nuechterlein K, Bracha S, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek P, Trenary M, Tafalla R, Reynolds C, Bunney W: Frontostriatal disorder of cerebral metabolism in never medicated schizophrenics. Arch Gen Psychiatry 1992;49:935–942.
- Guich SM, Buchsbaum MS, Burgwald L, Wu J, Haier R, Asarnow R, Nuechterlein K, Potkin S: Effect of attention on frontal distribution of delta activity and cerebral metabolic rate in schizophrenia. Schizophr Res 1989;2:439–448.
Overall JE, Gorham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962;10:799–812.
- Buchsbaum MS, Gillin JC, Wu J, Hazlett E, Sicotte N, DuPont RM: Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography. Life Sci 1989;45:1349–1356.
- Nuechterlein KH, Parasuraman R, Jiang Q: Visual sustained attention: Image degradation produces rapid decrement over time. Science 1983;220:327–329.
Matsui T, Hirano A: An atlas of the human brain for computerized tomography. Tokyo, Igaku-Shoin, 1978.
Buchsbaum MS, Abel L, Mucci A, Guich S, Tang C: Simultaneous electroencephalographic and cerebral metabolic rate measurement; in Maurer K (ed): Imaging of the Brain in Psychiatry and Related Fields. Berlin, Springer, 1993.
Hays WL: Statistics, ed 4. Fort Worth, Holt Rinehart Winston, 1988, pp 590–592.
- Buchsbaum MS, Nuechterlein KH, Haier RJ, Wu J, Sicotte N, Asarnow R, Potkin S, Guich S: Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. Br J Psychiatry 1990;156:216–227.
- van den Bosch RJ, Rombouts RP, van Asma MJO: What determines continuous performance task performance? Schizophr Bull 1996;22:643–651.
- Jacquy J, Charles P, Piraux A, Noel G: Relationship between the electroencephalogram and the rheoencephalogram in the normal young adult. Neuropsychobiology 1980;6:341–348.
- Tanaka A, Kimura M, Yoshinaga S, Tomonaga M, Mizoguchi T: Quantitative electroencephalographic correlates of cerebral blood flow in patients with chronic subdural hematomas. Surg Neurol 1998;50:235–240.
- Mallet L, Mazoyer B, Martinot JL: Functional connectivity in depressive, obsessive-compulsive, and schizophrenic disorders: An explorative correlational analysis of regional cerebral metabolism. Psychiatry Res 1998;82:83–93.
Steriade M, Jones EG, McCormick DA: Thalamus. Amsterdam, Elsevier, 1997, vol 1, pp 31–35.
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