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Can an Autocrine Loop Explain Sex-Hormone-Dependent Tumor Growth?

A Brief Overview

Sato B.

Author affiliations

Third Department of Internal Medicine, Nissay Hospital, Osaka, Japan

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Oncology 1999;57(suppl 2):3–6

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 21, 1999
Issue release date: October 1999

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Sex hormones and their related compounds have been known to regulate the target cell growth positively or negatively in the receptor-dependent manner. The molecular mechanism of these complicated events, especially sex hormone-dependent growth enhancement, has been studied extensively. In MCF-7 cells, estrogen-induced autocrine loop has been demonstrated to play the important role for estrogen-dependent growth. Androgen has been also found to promote the growth of SC-3 cell through the induction of an autocrine growth factor (FGF 8). The blockade of FGF 8 activity resulted in a complete inhibition of androgen-dependent growth of SC-3 cells, suggesting that FGF 8 acts as an essential component of androgen-dependent growth. However, the constitutional expression of FGF 8 failed to convert SC-3 cells from an androgen-dependent to an androgen-independent phenotype. These observations would suggest that sex hormone-induced autocrine loop is an obligatory but not sufficient component for the growth of sex hormone-dependent tumor.


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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 21, 1999
Issue release date: October 1999

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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