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Laboratory/Clinical Translational Research

Expression of p57/Kip2 Protein in Hepatocellular Carcinoma

Ito Y.a,b · Takeda T.a · Sakon M.c · Tsujimoto M.d · Monden M.c · Matsuura N.b

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aDepartment of Surgery, Osaka Seamen’s Insurance Hospital, bDepartment of Pathology, School of Allied Health Science, Osaka University Faculty of Medicine, cDepartment of Surgery II, Osaka University Medical School, and dDepartment of Pathology, Osaka Police Hospital, Osaka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Published online: September 26, 2001
Issue release date: September 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Evaluation of the biological character of carcinomas requires understanding of cell cycle regulators. In the present study, we investigated the expression of p57 (Kip2) in 90 hepatocellular carcinomas and 66 noncancerous lesions. The average p57 labeling index in noncancerous lesions was 72.3 ± 19.7. The labeling index significantly decreased (p < 0.0001) in hepatocellular carcinoma (54.9 ± 19.7). It was significantly lower in hepatocellular carcinoma cases with high biological aggressiveness such as advanced stage (p = 0.0041), poor differentiation (p < 0.0001), larger size (p = 0.0400), portal invasion (p < 0.0001), satellite tumor (p = 0.0023), high proliferating activity (p = 0.0002) and cyclin D1 overexpression (p = 0.0416). Furthermore, cases with low p57 expression showed worse outcomes for disease-free survival in univariate analysis (p = 0.0235), although p57 expression could not be recognized as an independent prognostic factor. These findings suggest that p57 contributes to the downregulation of cell proliferation and to the progression of hepatocellular carcinoma.

© 2001 S. Karger AG, Basel


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    External Resources

Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Published online: September 26, 2001
Issue release date: September 2001

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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