Ophthalmic Research

Original Paper

Evaluation of the Circulation in the Retina, Peripapillary Choroid and Optic Disk in Normal-Tension Glaucoma

Sugiyama T.a · Schwartz B.b,c · Takamoto T.c · Azuma I.a

Author affiliations

aDepartment of Ophthalmology, Osaka Medical College, Takatsuki, Japan; bTufts University School of Medicine and cGlaucoma Research Inc., Boston, Mass., USA

Keywords: Normal-tension glaucomaFluorescein angiographyBlood flowRetinaPeripapillary choroidOptic disk

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Ophthalmic Res 2000;32:79–86
https://doi.org/10.1159/000055594

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 10, 2000
Issue release date: March – June

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 7

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

Computerized image analysis, including fluorescein angiography, was used to evaluate the retinal, choroidal and optic disk blood flow in 16 patients with normal-tension glaucoma (NTG) and to correlate this measurement with visual fields, retinal vessel width, optic disk pallor and blood pressure (BP). The angle of the ascending slope of the fluorescein dye curve was measured as an index of blood flow from the densitometric and time curves of the fluorescein angiograms in the optic disk, peripapillary choroid, retinal artery and vein for each quadrant. While the ascending slope as well as the retinal vessel width were most reduced in the inferior and nasal regions, the mean threshold was lowest in the superior and nasal quadrants. There were positive significant correlations between artery width and threshold value, between angles of slopes and pallor. In addition, systolic BP had a negative correlation with pallor, and diastolic BP had a positive one with slope in the choroid. These results indicated the probable association of a decrease in retinal, choroidal and optic disk blood flow in the inferior and nasal quadrants as well as vessel width in the inferior nasal quadrant with visual field loss in the superior quadrant, and also demonstrated an increasing blood flow for enlargement of pallor. A decrease in BP was found to be related to reduced blood flow in choroid and optic disk impairment.

© 2000 S. Karger AG, Basel



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References

  1. Collaborative normal-tension glaucoma study group: Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressure. Am J Ophthalmol 1998;126:487–497.
    External Resources
  2. Chumbery LC, Brubaker RF: Low tension glaucoma. Am J Ophthalmol 1976;81:761–767.
    External Resources
  3. Levene RZ: Low tension glaucoma: A critical review and new material. Surv Ophthalmol 1980;24:621–664.
    External Resources
  4. Drance SM, Begg IS: Sectorial hemorrhage, a probable acute ischemic disc change in chronic simple glaucoma. Can J Ophthalmol 1970;5:137–141.
    External Resources
  5. Kitazawa Y, Shirato S, Yamamoto T: Optic disc hemorrhage in low-tension glaucoma. Ophthalmology 1986;93:853–857.
    External Resources
  6. Rockwood EJ, Anderson DR: Acquired peripapillary changes and progression in glaucoma. Graefe’s Arch Clin Exp Ophthalmol 1988;226:510–515.
  7. Drance SM, Douglas GR, Wijisman K, Shulzer M, Britton RJ: Response of blood flow to warm and cold in normal and low-tension glaucoma patients. Am J Ophthalmol 1988;105:35–39.
    External Resources
  8. Flammer J, Guthauser U, Mahler F: Do ocular vasospasms help cause low tension glaucoma? Doc Ophthalmol Proc Ser 1987;49:397–399.
  9. Phelps CD, Corbett JJ: Migraine and low-tension glaucoma – A case control study. Invest Ophthalmol Vis Sci 1985;26:1105–1108.
    External Resources
  10. Kitazawa Y, Shirai H, Go FJ: The effect of Ca2+ antagonist on visual field in low-tension glaucoma. Graefe’s Arch Clin Exp Ophthalmol 1989;227:408–412.
  11. Sawada A, Kitazawa Y, Yamamoto T, Okabe I, Ichien K: Prevention of visual field progression with brovincamine in eyes with normal-tension glaucoma. Ophthalmology 1996;103:283–288.
    External Resources
  12. Pillunat LE, Lang GK, Harris A: The visual response to increased ocular blood flow in normal pressure glaucoma. Surv Ophthalmol 1994;38(suppl):S33–S39.
  13. Ben-Nun J, Nemet P: Intraocular pressure and blood flow of the optic disk: A fluorescent blood cell angiography study. Surv Ophthalmol 1995;39(suppl):S33–S39.
  14. Geijssen HC: Studies on Normal Pressure Glaucoma. Amsterdam, Kugler, 1991.
  15. Hitching RA, Spaeth GL: Fluorescein angiography in chronic simple and low-tension glaucoma. Br J Ophthalmol 1977;61:126–132.
    External Resources
  16. Moses RA: Intraocular blood flow from analysis of angiograms. Invest Ophthalmol Vis Sci 1983;24:354–360.
    External Resources
  17. Schwartz B, Kern J: Age, increased ocular and blood pressures, and retinal and disc fluorescein angiogram. Arch Ophthalmol 1980;98:1980–1986.
    External Resources
  18. Schwartz B: Circulatory defects of the optic disk and retina in ocular hypertension and high pressure open-angle glaucoma. Surv Ophthalmol 1994;38(suppl):S23–S34.
  19. Sonty S, Schwartz B: Two-point fluorophotometry in the evaluation of glaucomatous optic disc. Arch Ophthalmol 1980;98:1422–1426.
    External Resources
  20. van Stokkum IH, Lambrou GN, van den Bert TJ: Haemodynamic estimation from ocular fluorescein angiograms. Graefe’s Arch Clin Exp Ophthalmol 1995;233:123–130.
  21. Talusan ED, Schwartz B, Wilcox LM Jr: Fluorescein angiography of the optic disc: A longitudinal follow-up study. Arch Ophthalmol 1980;98:1579–1587.
    External Resources
  22. James CB, Smith SE: Pulsatile ocular blood flow in patients with low tension glaucoma. Br J Ophthalmol 1991;75:466–470.
    External Resources
  23. Harris A, Sergott RC, Spaeth GL, Katz JL, Shoemaker JA, Martin BJ: Color Doppler analysis of ocular vessel blood velocity in normal tension glaucoma. Am J Ophthalmol 1994;118:642–649.
    External Resources
  24. Rankin SJ, Walman BE, Buckley AR, Drance SM: Color Doppler imaging and spectral analysis of the optic nerve vasculature in glaucoma. Am J Ophthalmol 1995;119:685–693.
    External Resources
  25. Rojanapongpun P, Drance SM, Morrison BJ: Ophthalmic artery flow velocity in glaucomatous and normal subject. Br J Ophthalmol 1993;77:25–29.
    External Resources
  26. Yamazaki Y, Hayamizu F: Comparison of flow velocity of ophthalmic artery between primary open angle glaucoma and normal tension glaucoma. Br J Ophthalmol 1995;79:732–734.
    External Resources
  27. Feke GT, Schwartz B, Takamoto T, Fujio N, Konno S, Goger DG, Nangia V: Optic nerve head circulation in untreated ocular hypertension. Br J Ophthalmol 1995;79:1088–1092.
    External Resources
  28. Hamard P, Hamard H, Dufaux J, Quesnot S: Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma. Br J Ophthalmol 1994;78:449–453.
    External Resources
  29. Riva CE, Harino S, Petrig BL, Shonat RD: Laser Doppler flowmetry in the optic nerve. Exp Eye Res 1992;55:499–506.
    External Resources
  30. Michelson G, Langhans MJ, Groh MJ: Perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open angle glaucoma. J Glaucoma 1996;5:91–98.
    External Resources
  31. Bengtssen B, Krakau CE: Correction of optic disc measurements on fundus photographs. Graefe’s Arch Clin Exp Ophthalmol 1992;230:24–28.
  32. O’Brien C, Schwartz B, Takamoto T: Correlation of Optic Disc Cupping, Pallor and Retinal Nerve Fiber Layer Thickness with Visual Field Loss in Chronic Open Angle Glaucoma. Perimetry Update 1990/91. Amsterdam, Kugler, 1991, pp 15–22.
  33. Nagin P, Schwartz B, Nanba K: The reproducibility of computerized boundary analysis for measuring optic disc pallor in the normal optic disc. Ophthalmology 1985;92:243–251.
    External Resources
  34. Wu DC, Schwartz B, Schwoerer J, Banwatt R: Retinal blood vessel width measured on color fundus photographs by image analysis. Acta Ophthalmol Scand 1995;73(suppl 215):33–40.
  35. Bland JM, Altman DG: Multiple significance tests: The Bonferroni method. Br Med J 1995;310:170.
  36. Araie M, Yamagami J, Suzuki Y: Visual field defects in normal-tension and high-tension glaucoma. Ophthalmology 1993;100:1808–1814.
    External Resources
  37. Nyman K, Tomita G, Raitta C, Kawamura M: Correlation of asymmetry of visual field loss with optic disc topography in normal-tension glaucoma. Arch Ophthalmol 1994;112:349–353.
    External Resources
  38. Schwartz B, Harris A, Takamoto T, Evans D: Ocular circulation map. ARVO abstract. Invest Ophthalmol Vis Sci Suppl 1997;28:S1169.
  39. Jonas JB, Schiro D: Visibility of the normal retinal nerve fiber layer correlated with rim width and vessel caliber. Graefe’s Arch Clin Exp Ophthalmol 1993;231:207–211.
  40. Jonas JB, Naumann GOH: Parapapillary retinal vessel diameter in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci 1989;30:1604–1611.
    External Resources
  41. Grunwald JE, Riva CE, Baine J, Brucker AJ: Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control. Invest Ophthalmol Vis Sci 1992;33:356–363.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 10, 2000
Issue release date: March – June

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 7

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

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2000, Vol.32, No. 2-3

March – June

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