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Original Paper

Aqueous Humor and Serum Tumor Necrosis Factor-α in Clinical Uveitis

Santos Lacomba M.a · Marcos Martín C.a · Gallardo Galera J.M.a · Gómez Vidal M.A.d · Collantes Estévez E.b · Ramírez Chamond R.c · Omar M.M.d

Author affiliations

aDepartment of Ophthalmology, bDepartment of Rheumatology, and cDepartment of Experimental Medicine, Reina Sofia University Clinic, Cordoba, and dDepartment of Internal Medicine, Ciudad de Jaen University Clinic, Jaen, Spain

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Ophthalmic Res 2001;33:251–255

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 01, 2001
Issue release date: September – October

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

Objective: To study the local and systemic behavior of the tumor necrosis factor-α (TNF-α) in patients with active uveitis. Methods: TNF-α levels were measured in aqueous humor and peripheral blood samples using an enzyme-linked immunosorbent assay from 23 patients with uveitis and 16 control patients who had been operated on for uncomplicated cataracts. Results: Aqueous humor and sera of patients with uveitis showed higher levels of TNF-α than those of controls (p < 0.001). A comparison of cytokine levels between aqueous humor and sera showed significantly higher levels of TNF-α in serum than aqueous humor (p < 0.001). Correlation studies using the regression test for successive steps showed that serum TNF-α levels correlated with recurrent uveitis (r = 0.4150; p = 0.0489). Conclusions: TNF-α is a cytokine that participates actively in the pathogenesis of clinical uveitis. Our data emphasize the greater systemic than local participation of TNF-α. Finally, an elevated serum TNF-α seems to be associated with a recurrent pattern of uveitis.

© 2001 S. Karger AG, Basel


References

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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 01, 2001
Issue release date: September – October

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE


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