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Original Paper

Intratumoral Therapy with Bleomycin for Cystic Craniopharyngiomas in Children

Hader W.J.a · Steinbok P.a,b · Hukin J.c,d · Fryer C.d

Author affiliations

aDivision of Neurosurgery, Department of Surgery, bDivision of Neurosurgery, B.C.’s Children’s Hospital, and Divisions of cNeurology and dOncology, Department of Pediatrics, University of British Columbia and B.C.’s Children’s Hospital, Vancouver, British Columbia, Canada

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Pediatr Neurosurg 2000;33:211–218

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 07, 2000
Issue release date: October 2000

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE

Abstract

Surgical removal of cystic craniopharyngiomas in children is associated with significant operative morbidity and recurrence rates. The purpose of this study was to review our experience with a less invasive therapy, namely, intratumoral bleomycin, in the treatment of predominantly cystic craniopharyngiomas. All children with craniopharyngiomas treated at a tertiary care pediatric neurosurgical center since 1994, when bleomycin was first used, were reviewed retrospectively. Seven patients received intratumoral bleomycin therapy. Patients received 2–5 mg bleomycin per dose, 3 times per week, for 3–5 weeks as an initial course. Mean follow-up of these patients was 3 years. In 4 patients, treatment resulted in a significant decrease (>50%) in tumor size, which has remained stable. Two patients’ tumors progressed and underwent resection, and 1 patient had surgical removal because of persistent headaches, although no growth of residual tumor had been noted. One patient developed peritumoral edema as a result of bleomycin therapy. Intratumoral bleomycin is a useful alternative therapy for cystic craniopharyngiomas, and may control tumor growth and delay potentially harmful resection and/or radiotherapy in young children.

© 2000 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: December 07, 2000
Issue release date: October 2000

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: https://www.karger.com/PNE


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