Pharmacology

Original Paper

Effects of Nicorandil Administration on Survival Rate and Arrhythmias during Reperfusion in Anesthetized Rabbits

Das B.a · Sarkar C.a · Karanth K.S.b

Author affiliations

aDepartment of Pharmacology, Kasturba Medical College, Manipal, Karnataka; bDepartment of Pharmacology, K.S. Hegde Medical Academy, Deralekatte, Mangalore, India

Keywords: NicorandilKATP channelAnesthetized rabbitCoronary occlusionReperfusion arrhythmia

Related Articles for ""
Pharmacology 2001;63:134–141
https://doi.org/10.1159/000056124

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 05, 2001
Issue release date: October 2001

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 6

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The aim was to study the effects of nicorandil (an ATP-sensitive K+ channel opener) and tolbutamide (an ATP-sensitive K+ channel blocker) on reperfusion-induced arrhythmias in pentobarbitone and ketamine anesthetized rabbits. Arrhythmias were induced by reperfusion for 20 min following a 15-min ligation of the left main coronary artery with a silk ligature. Rabbits were pretreated with nicorandil (0.47, 0.93 or 1.86 mg/kg i.v.) or tolbutamide (180 mg/kg i.p.) or vehicle (dimethylsulfoxide/saline) before the coronary artery occlusion. In the control group (n = 10), only 60% of the animals survived during reperfusion. Intravenous pretreatment with 0.47, 0.93 or 1.86 mg/kg of nicorandil increased the survival rate to 86% (n = 7), 75% (n = 8) and 86% (n = 7), respectively. Nicorandil pretreatment significantly decreased the incidence and duration of reperfusion-induced life-threatening arrhythmias and increased the number of animals that survived without developing any arrhythmia. Tolbutamide pretreatment was associated with a decreased survival rate of 50% (n = 12) and an increase in the incidence and duration of reperfusion-induced arrhythmias. Pretreatment with nicorandil may result in protection against reperfusion-induced arrhythmias and increased survival in anesthetized rabbits.

© 2001 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: October 05, 2001
Issue release date: October 2001

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 6

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

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2001, Vol.63, No. 3

October 2001

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