Gene Mapping, Cloning and Sequencing
Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14Caldwell G.M.a · Eddy R.L.a · Day C.D.a · Haley L.H.a · Cooper P.R.a · Sait S.S.J.b · Hejtmancik F.c · Smith R.J.H.d · Morton C.C.e · Higgins M.J.a · Shows T.B.a
Departments of aCancer Genetics and bCytogenetics, Roswell Park Cancer Institute, Buffalo NY; cNational Eye Institute, National Institutes of Health, Bethesda MD; dDepartment of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City IA; eDepartment of Pathology, Brigham & Women’s Hospital, Boston MA (USA)
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We have identified a number of transcribed sequences within a 400-kb interval on chromosome 11p15.1→ p14. Six genes and 13 novel transcripts including ESTs, cDNAs and exons have been identified and assigned to this region. Comparison of mRNA sequence with genomic sequence has enabled us to determine the exon/intron structure of four of the genes (NUCB2, PIK3C2A, RPS13 and OR7E14P).
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