Animal Cytogenetics and Comparative Mapping
The human hedgehog-interacting protein gene: Structure and chromosome mapping to 4q31.21→q31.3Bak M. · Hansen C. · Friis Henriksen K. · Tommerup N.
Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen (Denmark)
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Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21→ q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
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