Gene Mapping, Cloning and Sequencing
Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC)Iacobazzi V.a · Ventura M.b · Fiermonte G.a · Prezioso G.a · Rocchi M.b · Palmieri F.a
Departments of aPharmaco-Biology and bPathological Anatomy and Genetics, University of Bari, Bari (Italy)
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The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis. The human DNC gene (SLC25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcripts, which differ in their 5′ ends and are generated by alternative splicing, have been identified.
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