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Original Article · Originalarbeit

A Non-Randomised Pilot Study to Compare Complementary and Conventional Treatments of Acute Sinusitis

Weber U.a · Luedtke R.b · Friese K.-H.c · Fischer I.d · Moeller H.a

Author affiliations

aKinderklinik des Universitätsklinikums Tübingen; bKarl und Veronica Carstens-Stiftung, Essen; cWeil der Stadt; dInstitut für Medizinische Informationsverarbeitung, Universitätsklinikum Tübingen

Related Articles for ""

Forsch Komplementärmed Klass Naturheilkd 2002;9:99–104

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: November 17, 2004
Issue release date: April 2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR

Abstract

Background: It is still under discussion whether antibiotics are effective in the treatment of acute sinusitis. Moreover, they are known to have considerable side-effects. In contrast, complementary approaches are reported to have little side-effects and an equivalent efficiency. Objectives: To assess the success of conventional and complementary treatments of acute sinusitis and to estimate the patient numbers needed to confirm therapeutic equivalence. Treatment success was measured by three different scores, assessed by both patients and physicians. Methods: Multicentre (2 complementary and 3 conventional ENT centres), non-randomised, controlled clinical trial with 63 patients (complementary group 30, conventional group 33 patients). To control for confounders treatment differences were estimated by propensity score techniques. Treatments: The choice of medication was entirely left to the physician. We recommended to use antibiotics, secretolytics and symptomimetics in the conventional group and a combination of the herbal remedy Sinupret® and the homeopathic remedy Cinnabaris 3X in the complementary group. Results: Treatment differences varied substantially depending on the outcome measure, but they were always not clinically relevant. Conventional treatment was slightly better when the outcome was assessed by the physicians (1.8 score points) but slightly worse when it was assessed by patients (0.2 score points) or in terms of the HCG-5 quality of life score (0.8 score points). p values were always > 0.3. Conclusions: Both treatments appear to be equally effective (or ineffective). Results might be biased because both treatment groups differed substantially. Randomised trials including at least 400 patients are needed to produce valid results.

© 2002 S. Karger GmbH, Freiburg


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: November 17, 2004
Issue release date: April 2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR


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