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Original Research Article

Clinical Efficacy of Piracetam in Cognitive Impairment: A Meta-Analysis

Waegemans T.a · Wilsher C.R.a · Danniau A.a · Ferris S.H.b · Kurz A.c · Winblad B.d

Author affiliations

aResearch and Development, UCB SA (Pharma Sector), Braine-l’Alleud, Belgium; bThe William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, N.Y., USA; cDepartment of Psychiatry, Technische Universität München, München, Germany; dAlzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden

Related Articles for ""

Dement Geriatr Cogn Disord 2002;13:217–224

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: May 02, 2002
Issue release date: May 2002

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

A meta-analysis has been performed including nineteen double blind, placebo controlled studies with piracetam in patients suffering from dementia or cognitive impairment in the elderly. These studies had as common outcome measure a clinical global impression of change, a measure of clinically meaningful improvement. The meta-analysis of this global outcome followed the methodology set forward by the Cochrane Collaboration. This article describes the studies, the patient populations and the methods of data extraction. The results of the meta-analysis demonstrate a difference between those individuals treated with piracetam and those given placebo, both as significant odds ratio and as a favourable number needed to treat. While there may be problems in meta-analyses and the interpretation of the statistical results, the results of this analysis provide compelling evidence for the global efficacy of piracetam in a diverse group of older subjects with cognitive impairment.

© 2002 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: May 02, 2002
Issue release date: May 2002

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.