Gene Mapping, Cloning and Sequencing
Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150GluedPushkin A. · Abuladze N. · Newman D. · Tatishchev S. · Kurtz I.
Division of Nephrology, UCLA School of Medicine, Los Angeles CA (USA)
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In eukaryotes, it is rare for a single gene to encode two functionally unrelated proteins. p150Glued is a component of the dynactin heteromultimeric complex of proteins which is required for dynein-mediated vesicle and organelle transport by microtubules. NBC4 is an electrogenic sodium bicarbonate cotransporter, which regulates intracellular pH. Here we report that NBC4 and p150Glued are encoded by the same locus, DCTN1-SLC4A5. We have characterized the genomic organization of the human DCTN1-SLC4A5 locus which spans ∼230 kilobases on chromosome 2p13 and contains 66 exons. This information should allow the study of potential genomic alterations of DCTN1-SLC4A5 in patients with diseases mapping to this genomic region.
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