Annals of Nutrition and Metabolism
Original Paper
Supplementing Bovine Milk Immunoglobulin G Prevents Rats Fed on a Vitamin E-Deficient Diet from Developing Peroxidation StressZommara M.A. · Toubo H. · Imaizumi K.Graduate School of Bioresource and Bioenvironmental Sciences, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan
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Ann Nutr Metab 2002;46:97–102
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Article / Publication Details
First-Page Preview
Received: September 28, 2000
Accepted: January 14, 2002
Published online: August 07, 2002
Issue release date: May – August
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Abstract
Background/Aims: Bovine milk whey, which mainly includes β-lactoglobulin (58%), α-lactalbumin (22%) and immunoglobulin G (IgG; 11%), is a source of a wide range of proteins with a useful nutritional and physiological function. We previously demonstrated antiperoxidative effects of whey-derived α-lactalbumin and β-lactoglobulin in rats. The aim of the present study was to investigate the role of the IgG in antiperoxidative properties. Methods: Four-week-old, male Sprague-Dawley rats were fed a vitamin E-deficient diet (control) or a diet supplemented with 2.5% of an IgG-rich fraction for 4 weeks. Different antiperoxidative parameters were measured in blood and liver from the rats. Results: In comparison to the rats fed the control diet, those fed the IgG-containing diet were resistant to peroxidation stress. The IgG diet resulted in a decreased concentration of thiobarbituric acid-reactive substances in red blood cells (RBC) and plasma, and increased activities of catalase, superoxide dismutase and glutathione peroxidase in the RBC and liver. The plasma density (d) < 1.063 g/ml lipoproteins from the IgG group were more resistant against the induced lipid peroxidation. Conclusion: These results demonstrate antiperoxidative properties of IgG. The underlying mechanism(s) remain to be determined.
© 2002 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Received: September 28, 2000
Accepted: January 14, 2002
Published online: August 07, 2002
Issue release date: May – August
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
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