Tumor Biology
Research Article
Serum Levels of Soluble Transferrin Receptor Correlate with Severity of Disease but Not with Iron Stores in Patients with Malignant LymphomasBjerner J. · Amlie L.-M. · Rusten L.S. · Jakobsen E.Central Laboratory, Norwegian Radium Hospital, Montebello, Oslo, Norway
|
|
Tumor Biol 2002;23:146–153
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Subscribe
For eJournal Archive and eJournal Backfiles information please contact Karger service
* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details
First-Page Preview
Received: March 05, 2002
Accepted: May 23, 2002
Published online: September 05, 2002
Issue release date: September 2002
Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3
ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)
For additional information: https://www.karger.com/TBI
Abstract
Soluble transferrin receptor levels in serum (s-sTfR) may be useful in differentiating between iron deficiency anemia and anemia of chronic disease. However, there is both theoretical and clinical evidence for elevated s-sTfR levels in patients with various hematological malignancies. In the present study, routine bone marrow aspirations were performed in 82 patients with malignant lymphomas (63 with non-Hodgkin’s lymphoma and 19 with Hodgkin’s disease). Smears were stained for evaluation of iron stores and graded. Patients were also given a disease score based on bone marrow morphology, erythrocyte sedimentation rate and LDH. s-sTfR levels correlated better with disease score [partial Spearman rank correlation coefficient (rs) controlled for iron stores was 0.51 (95% confidence interval 0.39–0.65); p < 0.001] than with iron stores [partial rs controlled for disease score was –0.25 (95% confidence interval –0.44 to –0.03); p = 0.027]. This study showed elevated s-sTfR levels in patients with malignant lymphomas without any signs of iron deficiency anemia. The diagnosis of iron deficiency anemia should not be established upon the basis of s-sTfR alone in this group of patients.
© 2002 S. Karger AG, Basel
Related Articles:
References
- Kohgo Y, Niitsu Y, Kondo H, Kato J, Tsushima N, Sasaki K, Hirayama M, Numata T, Nishisato T, Urushizaki I: Serum transferrin receptor as a new index of erythropoiesis. Blood 1987;70:1955–1958.
- Feelders RA, Kuiper-Kramer EP, van Eijk HG: Structure, function and clinical significance of transferrin receptors. Clin Chem Lab Med 1999;37:1–10.
- Flowers CH, Skikne BS, Covell AM, Cook JD: The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989;114:368–377.
- Huebers HA, Finch CA: The physiology of transferrin and transferrin receptors. Physiol Rev 1987;67:520–582.
- Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA: Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990;75:102–107.
- Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD: Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990;265:19077–19081.
- Baynes RD, Shih YJ, Hudson BG, Cook JD: Production of the serum form of the transferrin receptor by a cell membrane-associated serine protease. Proc Soc Exp Biol Med 1993;204:65–69.
- Suominen P, Punnonen K, Rajamaki A, Irjala K: Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem 1997;43:1641–1646.
- Allen J, Backstrom KR, Cooper JA, Cooper MC, Detwiler TC, Essex DW, Fritz RP, Means RT Jr, Meier PB, Pearlman SR, Roitman-Johnson B, Seligman PA: Measurement of soluble transferrin receptor in serum of healthy adults. Clin Chem 1998;44:35–39.
- Vernet M, Doyen C: Assessment of iron status with a new fully automated assay for transferrin receptor in human serum. Clin Chem Lab Med 2000;38:437–442.
- Raya G, Henny J, Steinmetz J, Herbeth B, Siest G: Soluble transferrin receptor (sTfR): Biological variations and reference limits. Clin Chem Lab Med 2001;39:1162–1168.
- Choi JW, Pai SH, Im MW, Kim SK: Change in transferrin receptor concentrations with age. Clin Chem 1999;45:1562–1563.
- Choi JW, Im MW, Pai SH: Serum transferrin receptor concentrations during normal pregnancy. Clin Chem 2000;46:725–727.
- Kuvibidila S, Warrier RP, Ode D, Yu L: Serum transferrin receptor concentrations in women with mild malnutrition. Am J Clin Nutr 1996;63:596–601.
- van Iperen CE, Kraaijenhagen RJ, Biesma DH, Beguin Y, Marx JJ, van de Wiel A: Iron metabolism and erythropoiesis after surgery. Br J Surg 1998;85:41–45.
- Suominen P, Punnonen K, Rajamaki A, Irjala K: Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998;92:2934–2939.
- Goodnough LT, Skikne B, Brugnara C: Erythropoietin, iron, and erythropoiesis. Blood 2000;96:823–833.
- Punnonen K, Irjala K, Rajamaki A: Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997;89:1052–1057.
- Looker AC, Loyevsky M, Gordeuk VR: Increased serum transferrin saturation is associated with lower serum transferrin receptor concentration. Clin Chem 1999;45:2191–2199.
- Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD: Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992;119:385–390.
- Suominen P, Mottonen T, Rajamaki A, Irjala K: Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum 2000;43:1016–1020.
- Means RT Jr, Allen J, Sears DA, Schuster SJ: Serum soluble transferrin receptor and the prediction of marrow aspirate iron results in a heterogeneous group of patients. Clin Lab Haematol 1999;21:161–167.
- North M, Dallalio G, Donath AS, Melink R, Means RT Jr: Serum transferrin receptor levels in patients undergoing evaluation of iron stores: Correlation with other parameters and observed versus predicted results. Clin Lab Haematol 1997;19:93–97.
- Nielsen OJ, Andersen LS, Hansen NE, Hansen TM: Serum transferrin receptor levels in anaemic patients with rheumatoid arthritis. Scand J Clin Lab Invest 1994;54:75–82.
- Pettersson T, Kivivuori SM, Siimes MA: Is serum transferrin receptor useful for detecting iron-deficiency in anaemic patients with chronic inflammatory diseases? Br J Rheumatol 1994;33:740–744.
- Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG: Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998;44:45–51.
- Carmel R, Skikne BS: Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency. Eur J Haematol 1992;49:246–250.
- Rees DC, Williams TN, Maitland K, Clegg JB, Weatherall DJ: Alpha thalassaemia is associated with increased soluble transferrin receptor levels. Br J Haematol 1998;103:365–369.
- Kohgo Y, Nishisato T, Kondo H, Tsushima N, Niitsu Y, Urushizaki I: Circulating transferrin receptor in human serum. Br J Haematol 1986;64:277–281.
- Beguin Y, Lampertz S, Bron D, Fillet G: Serum erythropoietin in chronic lymphocytic leukaemia. Br J Haematol 1996;93:154–156.
- Klemow D, Einsphar D, Brown TA, Flowers CH, Skikne BS: Serum transferrin receptor measurements in hematologic malignancies. Am J Hematol 1990;34:193–198.
- Kato J, Kohgo Y, Kondo H, Nishisato T, Sasaki K, Tsushima N, Hirayama M, Fujikawa K, Sintani N, Miyazaki E: Circulating transferrin receptor in acute leukemias. Int J Hematol 1992;56:161–165.
- Raaf HN, Jacobsen DW, Savon S, Green R: Serum transferrin receptor level is not altered in invasive adenocarcinoma of the breast. Am J Clin Pathol 1993;99:232–237.
- Dowlati A, Loo M, Bury T, Fillet G, Beguin Y: Soluble and cell-associated transferrin receptor in lung cancer. Br J Cancer 1997;75:1802–1806.
- Beguin Y, Lampertz S, De Groote D, Igot D, Malaise M, Fillet G: Soluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia. Leukemia 1993;7:2019–2025.
- Suominen P, Punnonen K, Rajamaki A, Majuri R, Hanninen V, Irjala K: Automated immunoturbidimetric method for measuring serum transferrin receptor. Clin Chem 1999;45:1302–1305.
-
Cook J: The nutritional assessment of iron status. Arch Latinoam Nutr 1999;49(3 suppl 2):11S–14S.
- Buhl SN, Jackson KY: Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 degrees C. Clin Chem 1978;24:828–831.
- ICSH: Reference method for the erythrocyte sedimentation rate (ESR) test on human blood. Br J Haematol 1973;24:671–673.
- Bezwoda WR, Bothwell TH, Torrance JD, MacPhail AP, Charlton RW, Kay G, Levin J: The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand J Haematol 1979;22:113–120.
- R’zik S, Beguin Y: Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors. Exp Hematol 2001;29:677–685.
- Nejmeddine F, Raphael M, Martin A, Le Roux G, Moretti JL, Caillat-Vigneron N: 67Ga scintigraphy in B-cell non-Hodgkin’s lymphoma: Correlation of 67Ga uptake with histology and transferrin receptor expression. J Nucl Med 1999;40:40–45.
- Luttropp CA, Jackson JA, Jones BJ, Sohn MH, Lynch RE, Morton KA: Uptake of gallium-67 in transfected cells and tumors absent or enriched in the transferrin receptor. J Nucl Med 1998;39:1405–1411.
- Woith W, Nusslein I, Antoni C, Dejica DI, Winkler TH, Herrmann M, Pirner K, Kalden JR, Manger B: A soluble form of the human transferrin receptor is released by activated lymphocytes in vitro. Clin Exp Immunol 1993;92:537–542.
- Glasova M, Konikova E, Kusenda J, Babusikova O: Flow cytometric detection of some activation and proliferation markers in human hematopoietic cell lines. Neoplasma 1996;43:381–388.
Article / Publication Details
First-Page Preview
Received: March 05, 2002
Accepted: May 23, 2002
Published online: September 05, 2002
Issue release date: September 2002
Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3
ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)
For additional information: https://www.karger.com/TBI
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
