Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Fenofibrate Increases Creatininemia by Increasing Metabolic Production of Creatinine

Hottelart C.a · El Esper N.a · Rose F.b · Achard J.-M.a · Fournier A.a

Author affiliations

Departments of aNephrology and bBiochemistry, CHU Amiens, France

Related Articles for ""

Nephron 2002;92:536–541

Do you have an account?

Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 28, 2002
Published online: September 26, 2002
Issue release date: September 2002

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Fenofibrate is a potent hypolipemic agent, widely used in patients with renal insufficiency in whom dyslipidemia is frequent. A moderate reversible increase in creatinine plasma levels is an established side effect of fenofibrate therapy, which mechanism remains unknown. We have previously reported that in 13 patients with normal renal function or moderate renal insufficiency, two weeks of fenofibrate therapy increased creatininemia without any changes in renal plasma flow and glomerular filtration rate [1]. In 13 additional patients, muscular enzymes (AST, GPT, CPK, LDH) and myoglobin were measured before and after 2 weeks on fenofibrate, and the values of creatininemia obtained by the Jaffé technique and HPLC were compared. CPK and AST activity and plasma myoglobin increased in 2 patients with fenofibrate, but muscular enzymes remained unchanged in the population as a whole, and were not correlated to the changes in creatininemia. The changes in creatininemia induced by fenofibrate measured by the Jaffé technique were strongly correlated to those measured by HPLC (r2 = 0.675, p = 0.0006). Analysis of the pooled data of the two arms of the study showed in 26 patients that two weeks of fenofibrate therapy efficiently reduced total cholesterol and triglycerides plasma levels, and raised creatininemia from 139 ± 8 to 160 ± 10 µmol/l (p < 0.0001), but confirmed that creatininuria also increased to the extent that creatinine clearance remained unchanged (68 ± 6 vs. 67 ± 6 ml/min, n.s.). It is concluded that the increase in creatininemia induced by fenofibrate in renal patients does not reflect an impairment of renal function, nor an alteration of tubular creatinine secretion, and is not falsely increased by a dosage interference. Fenofibrate-induced increase of daily creatinine production is neither readily explained by accelerated muscular cell lysis. It is proposed that fenofibrate increases the metabolic production rate of creatinine.

© 2002 S. Karger AG, Basel


References

  1. Hottelart C, El Esper N, Achard J-M, Pruna A, Fournier A: Le fenofibrate augmente la créatininémie mais n’altère pas le débit de filtration glomérulaire chez les patients présentant une insuffisance rénale modérée. Néphrologie 1999;20:41–44.
    External Resources
  2. Attman PO, Alaupovic P, Tavella M, Knight-Gibson C: Abnormal lipid and apolipoprotein composition of major lipoprotein density classes in patients with chronic renal failure. Nephrol Dial Transplant 1996;11:63–69.
  3. Grutzmacher P, Marz W, Peschke B, Gross W, Schoeppe W: Lipoproteins and apolipoproteins during the progression of chronic renal disease. Nephron 1988;50:103–111.
    External Resources
  4. Brown WV: Potential use of fenofibrate and other fibric acid derivatives in the clinic. Am J Med 1987;83:85–89.
    External Resources
  5. Blane GF: Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives. Am J Med 1987;83:26–36.
  6. Devuyst O, Goffin E, Pirson Y, Van Ypersele de Strihou C: Creatinine rise after fibrate therapy in renal graft recipients. Lancet 1993;341:840.
  7. Broeders N, Knoop C, Antoine M, Tielemans C, Abramowicz D: Fibrate-induced increase in blood urea and creatinine: Is gemfibrozil the only innocuous agent? Nephrol Dial Transplant 2000;15:1993–1999.
  8. Van Acker BAC, Koomen GCM, Koopman MG, De Waart DR, Arisz L: Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet 1992;340:1326–1329.
  9. Hilbrands LB, Artz MA, Wetzels JFM, Koene RAP: Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Kidney Int 1991;40:1171–1176.
  10. Smith HW: The Kidney. New York, Oxford University Press, 1951, vol 17.
  11. Deighan C, Caslake M, McConnell M, Boulton-Jones J, Packard C: Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease. J Am Soc Nephrol 2001;12:341–348.
    External Resources
  12. Levin A, Duncan L, Djurdjev O, et al: A randomized placebo-controlled double-blind trial of lipid lowering strategies in patients with renal insufficiency: Diet modification with or without fenofibrate. Clin Nephrol 2000;53:140–146.
  13. Rumpf KW, Barth M, Blech M, et al: Bezafibrate-induced myolysis and myoglobinuria in patients with impaired renal function. Klin Wochenschr 1984;62:346–348.
    External Resources
  14. Lageder H: Comparative double-blind investigation of bezafibrate and clofibrate in patients with primary hyperlipoproteinemia. Wien Klin Wochenschr 1980;92:95–101.
    External Resources
  15. Schneider J, Muhlfellner G, Kaffarnik H: Creatinine kinase in hyperlipoproteinemic patients treated with clofibrate. Artery 1980;8:164–170.
    External Resources
  16. Schneider J: Clinical importance of clofibrate induced increase of creatine kinase catalytic activity concentration in serum. J Clin Biochem 1981;19:539–540.
  17. Rouffy J, Sauvanet JP, Chanu B, et al: Fenofibrate: Hypolipaemic activity and safety in long-term treatment. Effects on HDL, LDL, VLDL and apoprotein B in short-term treatment. Nouv Presse Méd 1980;9:3747–3751.
    External Resources
  18. Blane GF: Efficacité et tolérance du fénofibrate: dix ans d’expérience. J Int Med 1988;122:70–74.
  19. Bakir R, Chanu B, Goy-Loeper J, Coll A: Evaluation à long terme de l’activité hypolipidémiante et de la tolérance du fénofibrate (observation de 1830 années-malades). Prog Med 1982;110:18–24.
  20. Gervois P, Chopin-Delannoy S, Fadel A, et al: Fibrates increase human REV-ERB alpha expression in liver via a novel peroxisome proliferator-activated receptor response element. Mol Endocrinol 1999;13:400–409.
    External Resources
  21. Casas F, Pineau T, Rochard P, et al: New molecular aspects of regulation of mitochondrial activity by fenofibrate and fasting. FEBS Lett 2000;482:71–74.
  22. Guerre-Millo M, Gervois P, Raspe E, et al: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000;275:16638–16642.
  23. Kockx M, Princen HM, Kooistra T: Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes: Role of the peroxisome proliferator-activated receptor-alpha. Thromb Haemost 1998;80:942–948.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 28, 2002
Published online: September 26, 2002
Issue release date: September 2002

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.