Fenofibrate Increases Creatininemia by Increasing Metabolic Production of CreatinineHottelart C.a · El Esper N.a · Rose F.b · Achard J.-M.a · Fournier A.a
Departments of aNephrology and bBiochemistry, CHU Amiens, France
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Fenofibrate is a potent hypolipemic agent, widely used in patients with renal insufficiency in whom dyslipidemia is frequent. A moderate reversible increase in creatinine plasma levels is an established side effect of fenofibrate therapy, which mechanism remains unknown. We have previously reported that in 13 patients with normal renal function or moderate renal insufficiency, two weeks of fenofibrate therapy increased creatininemia without any changes in renal plasma flow and glomerular filtration rate [
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