Skin Pharmacology and Physiology
Carotenoids and Protection against Solar UV RadiationStahl W. · Sies H.Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland
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Skin Pharmacol Appl Skin Physiol 2002;15:291–296
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Article / Publication Details
First-Page Preview
Published online: September 16, 2002
Issue release date: September – October
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)
For additional information: https://www.karger.com/SPP
Abstract
Upon exposure to UV light photooxidative reactions are initiated which are damaging to biomolecules and affect the integrity of cells and tissues. Photooxidative damage plays a role in pathological processes and is involved in the development of disorders affecting the skin. When skin is exposed to UV light, erythema is observed as an initial reaction. Carotenoids like β-carotene or lycopene are efficient antioxidants scavenging singlet molecular oxygen and peroxyl radicals generated in during photooxidation. When β-carotene was applied as such or in combination with α-tocopherol for 12 weeks, erythema formation induced with a solar light simulator was diminished from week 8 on. Similar effects were also achieved with a diet rich in lycopene. Ingestion of tomato paste corresponding to a dose of 16 mg lycopene/ day over 10 weeks led to increases in serum levels of lycopene and total carotenoids in skin. At week 10, erythema formation was significantly lower in the group that ingested the tomato paste as compared to the control group. No significant difference was found at week 4 of treatment. Thus, protection against UV light-induced erythema can be achieved by ingestion of a commonly consumed dietary source of lycopene. Such protective effects of carotenoids were also demonstrated in cell culture. The in-vitro data indicate that there is an optimal level of protection for each carotenoid.
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References
- Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L, Scharffetter-Kochanek K: UV-induced oxidative stress and photoaging. Curr Probl Dermatol 2001;29:83–94.
- Klotz LO, Holbrook NJ, Sies H: UVA and singlet oxygen as inducers of cutaneous signaling events. Curr Probl Dermatol 2001;29:95–113.
- Berneburg M, Krutmann J: Photoimmunology, DNA repair and photocarcinogenesis. J Photochem Photobiol B 2000;54:87–93.
- Thiele JJ, Schroeter C, Hsieh SN, Podda M, Packer L: The antioxidant network of the stratum corneum. Curr Probl Dermatol 2001;29:26–42.
- Landrum JT, Bone RA: Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys 2001;385:28–40.
-
Stahl W, Sies H: Protection against solar radiation – protective properties of antioxidants; in Gacomoni PU (ed): Sun Protection in Man. Amsterdam, Elsevier, 2002, pp 561–572.
-
Sies H: Biochemistry of oxidative stress. Angew Chem Int Ed 1986;25:1058–1071.
-
Truscott TG: The photophysics and photochemistry of the carotenoids. J Photochem Photobiol B Biol 1990;6:359–371.
-
Mathews-Roth MM, Pathak MA, Fitzpatrick TB, Harber LC, Kass EH: β-Carotene as an oral protective agent in erythropoietic protoporphyria. J Am Med Assoc 1974;228:1004–1008.
- Mathews-Roth MM: Systemic photoprotection. Dermatol Clin 1986;4:335–339.
- Stahl W, Sies H: Physical quenching of singlet oxygen and cis-trans isomerization of carotenoids. Ann NY Acad Sci 1993;691:10–19.
- Di Mascio P, Kaiser S, Sies H: Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532–538.
- Stahl W, Nicolai S, Briviba K, Hanusch M, Broszeit G, Peters M, Martin H-D, Sies H: Biological activities of natural and synthetic carotenoids: Induction of gap junctional communication and singlet oxygen quenching. Carcinogenesis 1997;18:89–92.
-
Baltschun D, Beutner S, Briviba K, Martin H-D, Paust J, Peters M, Röver S, Sies H, Stahl W, Steigel A, Stenhorst F: Singlet oxygen quenching abilities of carotenoids. Liebigs Ann 1997:1887–1893.
- Stahl W, Sundquist AR, Hanusch M, Schwarz W, Sies H: Separation of β-carotene and lycopene geometrical isomers in biological samples. Clin Chem 1993;39:810–814.
- Stahl W, Heinrich U, Jungmann H, von Laar J, Schietzel M, Sies H, Tronnier H: Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J Nutr 1998;128:903–907.
- Peng YM, Peng YS, Lin Y: A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human tissues. Cancer Epidemiol Biomarkers Prev 1993;2:139–144.
- Wingerath T, Sies H, Stahl W: Xanthophyll esters in human skin. Arch Biochem Biophys 1998;355:271–274.
- Stahl W, Heinrich U, Jungmann H, Sies H, Tronnier H: Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr 2000;71:795–798.
- Stahl W, Heinrich U, Wiseman S, Eichler O, Sies H, Tronnier H: Dietary tomato paste protects against UV-induced erythema in humans. J Nutr 2001;131:1449–1451.
- Garmyn M, Ribaya-Mercado JD, Russell RM, Bhawan J, Gilchrest BA: Effect of beta-carotene supplementation on the human sunburn reaction. Exp Dermatol 1995;4:104–111.
- Wolf C, Steiner A, Hönigsmann H: Do oral carotenoids protect human skin against ultraviolet erythema, psoralen phototoxicity, and ultraviolet-induced DNA damage? J Invest Dermatol 1988;90:55–57.
-
Gollnick HPM, Hopfenmüller W, Hemmes C, Chun SC, Schmid C, Sundermeier K, Biesalski HK: Systemic beta-carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: Results of the Berlin-Eilath study. Eur J Dermatol 1996;6:200–205.
- Mathews-Roth MM, Pathak MA, Parrish JA, Fitzpatrick TB, Kass EH, Toda K, Clemens W: A clinical trial of the effects of oral beta-carotene on the responses of human skin to solar radiation. J Invest Dermatol 1972;59:349–353.
- Lee J, Jiang S, Levine N, Watson RR: Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc Soc Exp Biol Med 2000;223:170–174.
- Godar DE, Wengraitis SP, Shreffler J, Sliney DH: UV doses of Americans. Photochem Photobiol 2001;73:621–629.
- Godar DE: UV doses of American children and adolescents. Photochem Photobiol 2001;74:787–793.
-
Sies H, Stahl W: Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995;62:1315S–1321S.
- Krinsky NI: The antioxidant and biological properties of the carotenoids. Ann NY Acad Sci 1998;854:443–447.
- Young AJ, Lowe GM: Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 2001;385:20–27.
- Lowe GM, Booth LA, Young AJ, Bilton RF: Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 1999;30:141–151.
- Palozza P, Luberto C, Calviello G, Ricci P, Bartoli GM: Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: Effects of oxygen partial pressure. Free Radic Biol Med 1997;22:1065–1073.
- Biesalski HK, Obermueller-Jevic UC: UV light, beta-carotene and human skin – beneficial and potentially harmful effects. Arch Biochem Biophys 2001;389:1–6.
- Mayne ST: β-Carotene, carotenoids, and disease prevention in humans. FASEB J 1996;10:690–701.
- Pryor WA, Stahl W, Rock CL: Beta carotene: From biochemistry to clinical trials. Nutr Rev 2000;58:39–53.
- Omaye ST, Krinsky NI, Kagan VE, Mayne ST, Liebler DC, Bidlack WR: β-Carotene: Friend or foe? Fundam Appl Toxicol 1997;40:163–174.
- Woodall AA, Britton G, Jackson MJ: Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: Relationship between carotenoid structure and protective ability. Biochim Biophys Acta 1997;1336:575–586.
- Burton GW, Ingold KU: β-Carotene: An unusual type of lipid antioxidant. Science 1984;224:569–573.
- Zhang P, Omaye ST: Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in human lung cells. Toxicol in vitro 2001;15:13–24.
- Obermüller-Jevic UC, Francz PI, Frank J, Flaccus A, Biesalski HK: Enhancement of the UVA induction of haem oxygenase-1 expression by beta-carotene in human skin fibroblasts. FEBS Lett 1999;460:212–216.
- Eichler O, Sies H, Stahl W: Divergent optimum levels of lycopene, β-carotene and lutein protecting against UVB irradiation in human fibroblasts. Photochem Photobiol 2002;75:503–506.
Article / Publication Details
First-Page Preview
Published online: September 16, 2002
Issue release date: September – October
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)
For additional information: https://www.karger.com/SPP
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