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Epilepsy

Stimulation of the Central Median Thalamic Nucleus for Epilepsy

Velasco F. · Velasco M. · Jimenez F. · Velasco A.L. · Marquez I.

Author affiliations

Unit for Stereotactic and Functional Neurosurgery, General Hospital and Unit for Medical Research in Neurophysiology, National Medical Center IMSS, Mexico City, Mexico

Related Articles for ""

13th Meet World Soc Stereotact Funct Neurosurg, Adelaide 2001. Stereotact Funct Neurosurg 2001;77:228–232

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Article / Publication Details

First-Page Preview
Abstract of Epilepsy

Published online: October 07, 2002
Issue release date: October 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Electrical stimulation of the centromedian thalamic nucleus (ESCM) has been used in cases of difficult to control seizures with multifocal onset in frontal and temporal lobes, as well as in cases of seizures with no evidence of focal onset, such as Lennox-Gastaut syndrome. The stimulation program consists of 1 min stimulation on one side, 4 min interval OFF stimulation and 1 min stimulation on the other side, alternating from one side to the other for 24 h, at 60–130 Hz, 2.5–5.0 V, 0.21–0.45 ms. 49 cases have been treated and followed for periods of 6 months to 15 years. Results indicate that ESCM is highly efficient to control generalized tonic clonic seizures (GTC), atypical absences (AA) and tonic seizures (TS) and less efficient to control complex partial seizures (CxP).

© 2002 S. Karger AG, Basel


References

  1. Hunter J, Jasper HH: Effects of thalamic stimulation in the unanaesthetized animal. Electroencephalogr Clin Neurophysiol 1945;1:305–324.
    External Resources
  2. Miller JW, Farandelli JA: The centralmedian nucleus: Thalamic site of seizure regulation. Brain Res 1990;508:297–300.
  3. Velasco F, Velasco M, Márquez I, Velasco G: Role of the centro median thalamic nucleus in the genesis, propagation, and arrest of epileptic activity. An electrophysiological study in man. Acta Neurochir (suppl) 1993;58:201–204.
  4. Schaltenbrand G, Bailey P: Introduction to Stereotaxis with an Atlas of the Human Brain. Stuttgart, Georg Thieme, 1959, Vol IV.
  5. Dempsey EW, Morison R S: The mechanisms of thalamo-cortical augmentation and repetition. Am J Physiol 1942;138:297–308.
  6. Monnier M, Kalberet M, Krupp P: Functional antagonism between diffuse reticular and intralaminar recruiting projections in medial thalamus. Exp Neurol 1960;2:271–289.
  7. Velasco M, Velasco F, Velasco AL, Brito F, Jiménez F, Márquez I, Rojas B: Electrocortical and behavioral responses produced by acute electrical stimulation of the human centromedian thalamic nucleus. Electroenceph Clin Neurophysiol 1996;102:461–471.
    External Resources
  8. Velasco F, Velasco M, Jiménez F, Velasco AL, Brito F, Rise M, Carrillo Ruiz J D: Predictors in the treatment of difficult to control seizures by electrical stimulation of the centro median thalamic nucleus. Neurosurgery 2000;47:295–304.

Article / Publication Details

First-Page Preview
Abstract of Epilepsy

Published online: October 07, 2002
Issue release date: October 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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