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Original Paper

Effect of Low-Molecular-Weight Heparin on Potassium Homeostasis

Abdel-Raheem M.M.a · Potti A.a,b · Tadros S.a · Koka V.a · Hanekom D.a · Fraiman G.b · Danielson B.D.c

Author affiliations

aDepartment of Medicine, University of North Dakota School of Medicine, bDepartment of Medicine, Division of Hematology, Veterans’ Affairs Medical Center, and cDepartment of Medicine, Division of Nephrology, Veterans’ Affairs Medical Center, Fargo, N. Dak., USA

Corresponding Author

Anil Potti, MD

Department of Internal Medicine, University of North Dakota School of Medicine

1919 N Elm Street, Fargo, ND 58102 (USA)

Tel. +1 701 293 4131, Fax +1 701 293 4145, E-Mail anilpotti@meritcare.com

Related Articles for ""

Pathophysiol Haemost Thromb 2002;32:107–110

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Background: Low-molecular-weight heparins (LMWHs) are being preferred to unfractionated heparin (UFH) because of their superior convenience and a comparable or slightly better toxicity profile. Whether LMWH has an inhibitory effect on aldosterone that causes hyperkalemia is yet uncertain. Methods: Twenty-eight patients (all male; mean age: 70 years, range 52–87 years) placed on LMWH therapy (40 mg subcutaneously every 12 h) for deep venous thrombosis prophylaxis after an operation were included in the study. Transtubular potassium concentration gradient (TTKG) was calculated 1 day prior to LMWH therapy and again after 4 days of treatment. Of the 28 patients enrolled in the study, we were able to calculate the TTKG in only 19 patients: 9 had a urinary osmolarity (either before or after LMWH therapy) less than the serum osmolarity, making the TTKG calculation unreliable. The Wilcoxon signed-rank test was used to analyze differences in the median serum potassium levels and TTKG before and after LMWH therapy. Results: All patients had adequate renal function (creatinine clearance >90 ml/min). Mean (± SD) serum potassium concentration before LMWH was 4.25 (± 0.40) mmol/dl. It increased to 4.35 (± 0.41) mmol/dl after initiating LMWH therapy (p = 0.09). Similarly, the mean (± SD) TKKG calculated was 5.52 (± 2.33) before and 5.97 (± 3.06) after 4 days of LMWH (p = 0.54). Conclusions: Unlike UFH, LMWH (Lovenox®) in doses used for postoperative prophylaxis against deep venous thrombosis does not seem to have a significant effect on potassium homeostasis.

© 2002 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 29, 2001
Accepted: February 16, 2002
Published online: October 03, 2002
Issue release date: October 2002

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT

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