Original Research Article
Release and Skin Distribution of Silicone-Related Compound(s) from a Silicone Gel Sheet in vitroShigeki S.a · Nobuoka N.a · Murakami T.b · Ikuta Y.c
aDivision of Plastic and Reconstructive Surgery, bDepartment of Biopharmaceutics, Institute of Pharmaceutical Sciences, cDepartment of Orthopedic Surgery, Hiroshima University School of Medicine, Hiroshima, Japan
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The efficacy of topical silicone gel sheeting in prevention and/or reduction of keloids and hypertrophic scars is well recognized. In the present study, we reexamined the possible release of silicone-related compound(s) from a commercially available silicone gel sheet (Cica-Care, Smith and Nephew, Hull, England) in aqueous media in vitro. The silicone gel sheet was also applied on the excised skin surface to examine the possible distribution of silicone-related compounds into the skin in vitro. Silicone-related compounds were measured as silicon by an inductively coupled plasma-atomic emission spectrophotometer. When a piece of silicone gel sheet was placed in phosphate buffer solution (pH 3–9) at 37°C for 7 days, the concentration of silicon in the medium increased with time, depending on the pH of the medium. This indicates that the released silicone-related compounds are water-soluble. When Cica-Care was applied on the surface of excised rat skin, human axilla skin and hypertrophic scars under hydrated conditions in vitro, silicon was detected in all skin samples. Greater distribution was observed in rat skin than in human axilla skin and hypertrophic scars. The release of silicone-related compounds from a silicone gel sheet (Cica-Care) and their distribution into the skin were demonstrated in vitro. Silicone-related compounds distributed into the skin may have pharmacological effects on the skin. Further investigation will be necessary to investigate in detail the action of silicone-related compounds on the proliferation of fibroblasts and excessive production of collagen.
- Datubo-Brown DD: Keloids: A review of the literature. Br J Plast Surg 1990;43:70–77.
- Dockery GL: Hypertrophic and keloid scars. J Am Podiatr Med Assoc 1995;85:57–60.
- Sawada Y, Sone K: Treatment of scars and keloids with a cream containing silicone oil. Br J Plast Surg 1990;43:683–688.
- Sawada Y, Sone K: Hydration and occulusion treatment for hypertrophic scars and keloids. Br J Plast Surg 1992;45:599–603.
- Gold MH: Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience. J Dermatol Surg Oncol 1993;19:912–916.
- Clugston PA, Vistnes MD, Perry LC, Maxwell GP, Fisher J: Evaluation of silicone-gel sheeting on early wound healing of linear incisions. Ann Plast Surg 1995;34:12–15.
- Fulton JE Jr: Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg 1995;21:947–951.
- Wong TW, Chiu HC, Chang CH, Lin LJ, Liu CC, Chen JS: Silicone cream occlusive dressing – A novel noninvasive regimen in the treatment of keloid. Dermatology 1996;192:329–333.
- Palmieri B, Gozzi G, Palmieri G: Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. Int J Dermatol 1995;34:506–509.
- Hirshowitz B, Lindenbaum E, Har-Shai Y, Feitelberg L, Tendler M, Katz D: Static-electric field induction by a silicone cushion for the treatment of hypertrophic and keloid scars. Plast Reconstr Surg 1998;101:1173–1183.
- Quinn KJ: Silicone gel in scar treatment. Burns Incl Therm Inj 1987;13:S33–S40.
- Williams C: Cica-Care: Adhesive gel sheet. Br J Nurs 1996;5:875–876.
- Murray JC, Pollack SV, Pinnell SR: Keloids: A review. J Am Acad Dermatol 1981;4:461–470.
- Rockwell WB, Cohen IK, Ehrlich HP: Keloids and hypertrophic scars: A comprehensive review. Plast Reconstr Surg 1989;84:827–837.
Van Meter CT, Gennaro AR: Inorganic pharmaceutical chemistry; in Hoover JE (ed): Remington’s Pharmaceutical Sciences. Easton, Mack Publishing 1970, pp 397–427.
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