Fetal Diagnosis and Therapy
Neural Tube Defects in the Offspring of Thalassemia CarriersIbba R.M.a · Zoppi M.A.a · Floris M.a · Manca F.a · Axiana C.a · Cao A.b · Monni G.aaDepartment of Obstetrics and Gynecology, Prenatal and Preimplantation Diagnosis and Fetal Therapy, Regional Hospital for Microcythemia, Cagliari, and bDepartment of Science, Biomedicine and Biotechnology, University of Cagliari, Italy
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Article / Publication Details
Received: October 03, 2001
Accepted: March 06, 2002
Published online: February 06, 2003
Issue release date: January – February
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1
ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)
For additional information: https://www.karger.com/FDT
Abstract
Objectives: The risk of neural tube defects (NTDs) is negatively correlated with maternal folate levels in early pregnancy. Thalassemia carriers often have reduced red cell folate contents. The aim of this study was to verify whether thalassemia carriers are at increased risk of having offspring with a NTD. Methods: We retrospectively evaluated the prevalence of thalassemia carriers among 75 women who had prenatal diagnoses of NTDs made at our center. Results: The prevalence of β-thalassemia carriers among the affected pregnancies was significantly higher than in the general population (22.5 versus 14%, p < 0.05, χ2 test). Conclusion: Although inconclusive, these data indicate that folate supplementation is mandatory among women with thalassemia who are planning a pregnancy.
© 2003 S. Karger AG, Basel
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Article / Publication Details
Received: October 03, 2001
Accepted: March 06, 2002
Published online: February 06, 2003
Issue release date: January – February
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 1
ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)
For additional information: https://www.karger.com/FDT
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