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Pharmacology and Treatment

A New Calcipotriol/Betamethasone Dipropionate Formulation (DaivobetTM) Is an Effective Once-Daily Treatment for Psoriasis vulgaris

Kaufmann R.a · Bibby A.J.b · Bissonnette R.e · Cambazard F.f · Chu A.C.c · Decroix J.g · Douglas W.S.d · Lowson D.b · Mascaro J.M.h · Murphy G.M.i · Stymne B.j

Author affiliations

aGoethe-Universität, Frankfurt, Germany; bLeo Pharmaceuticals, Princes Risborough, cHammersmith Hospital, London, and dMonklands Hospital, Airdrie, UK; eInnovaderm Research Inc., Montreal, Canada; fHôpital Nord, St-Etienne, France; gMouscron, Belgium; hHospital Clinic i Provincial, Barcelona, Spain; iBeaumont Hospital, Dublin, Ireland; jRegionsjukhuset RSÖ, Örebro, Sweden

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Dermatology 2002;205:389–393

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: May 22, 2002
Accepted: June 21, 2002
Published online: December 19, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Topical corticosteroids and calcipotriol have been used separately for many years to treat psoriasis. A new combination ointment has been formulated, which contains both calcipotriol and the corticosteroid betamethasone dipropionate. Objective: To compare the combination ointment with betamethasone dipropionate ointment, calcipotriol ointment and ointment vehicle in patients with psoriasis vulgaris. Methods: 1,603 patients were randomised to one of the 4 double-blind treatments used once daily for 4 weeks. Results: Themean percentage change in the PASI at the end of treatment was –71.3 (combination), –57.2 (betamethasone), –46.1 (calcipotriol) and –22.7 (vehicle). The mean difference of combination minus betamethasone was –14.2 (95% CI: –17.6 to –10.8, p < 0.001), of combination minus calcipotriol –25.3 (95% CI: –28.7 to –21.9, p < 0.001) and of combination minus vehicle –48.3 (95% CI: –53.2 to –43.4, p < 0.001). 6.0% of patients (combination) reported local adverse reactions compared to 4.9% (betamethasone), 11.4% (calcipotriol) and 13.6% (vehicle). Conclusion: Calcipotriol/betamethasone dipropionate combination ointment used once daily is well tolerated and more effective than either active constituent used alone.

© 2002 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: May 22, 2002
Accepted: June 21, 2002
Published online: December 19, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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