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Original Paper

Seizures in Cerebral Vein and Dural Sinus Thrombosis

Ferro J.M.a · Correia M.b · Rosas M.J.c · Pinto A.N.d · Neves G.e

Author affiliations

Departments of Neurology,aHospital de Santa Maria, Lisboa, bSanto António, Porto, cSão João, Porto, dFernando da Fonseca, Amadora, and eSão Pedro, Vila Real, Portugal

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Cerebrovasc Dis 2003;15:78–83

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 04, 2001
Accepted: May 08, 2002
Published online: January 08, 2003
Issue release date: January 2003

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

To describe early symptomatic and late seizures in a cohort of patients with acute cerebral vein and dural sinus thrombosis (CVDST) and to identify their determinants, we performed a prospective registry and follow-up study of CVDST patients admitted to 20 Portuguese hospitals, from June 1995 to June 1998. Of 91 registered patients, 31 (34%) had early symptomatic seizures; 29 (31.9%) as a presenting feature and 2 (2.1%) after admission. Early symptomatic seizures were more frequent in patients with motor and sensory deficits and in those with focal oedema/ischaemic infarcts or haemorrhages on admission CT/MR. On multivariate logistic regression analysis, sensory defects (OR = 7.8; 95% CI = 0.8–74.8) and a parenchymal lesion on admission CT/MR (OR = 3.7, 95% CI = 1.4–9.4) were found to be significant predictors of early symptomatic seizures. Seizures were directly related to acute death in 2 patients. Eight (9.5%) patients had late seizures, which were multiple in 4 (4.8%). Late seizures were more frequent in patients with early symptomatic seizures and with haemorrhage on admission CT/MR. Neither early symptomatic seizures nor late seizures were related to functional prognosis at the last follow-up (median = 1 year). There is a moderate risk of seizure recurrence early in the course and during the first year after CVDST. Seizures can be a cause of acute death, but might not have an independent influence on functional outcome. Pharmacological prevention of seizures after CVDST should probably be limited to patients with early symptomatic seizures and cerebral lesions on admission CT/MR.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 04, 2001
Accepted: May 08, 2002
Published online: January 08, 2003
Issue release date: January 2003

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED


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