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Original Paper

High Prevalence of Calcified Silent Neurocysticercosis in a Rural Village of Mexico

Fleury A.a,d · Gomez T.e · Alvarez I.e · Meza D.e · Huerta M.e · Chavarria A.b · Carrillo Mezo R.A.a · Lloyd C.f · Dessein A.c · Preux P.M.d · Dumas M.d · Larralde C.b · Sciutto E.b · Fragoso G.b

Author affiliations

aInstituto Nacional de Neurología y Neurocirugía Manuel Velazco Suarez (INNN), México City; bInstituto de Investigaciones Biomédicas (IIBM), Universidad Nacional Autónoma de México City, México; cInstitut National de la Santé et de la Recherche Médicale, Marseille, dInstitut d’Epidémiologie Neurologique et de Neurologie Tropicale (IENT), Limoges, France; eBenemérita Universidad Autónoma de Puebla (BUAP), fHospital General de Puebla, Puebla, México

Related Articles for ""

Neuroepidemiology 2003;22:139–145

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: March 13, 2003
Issue release date: March – April

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED

Abstract

Human neurocysticercosis (NC) is a parasitic disease caused by Taenia solium when its larvae lodge in the central nervous system. NC prevalence estimates are obscured by the variable and often asymptomatic clinical picture. While infection depends on exposure, severity is possibly related with various host factors (immunity, genes and gender). This epidemiological study of cranial CT scans in an endemic rural community found that 9.1% of apparently healthy subjects had calcified lesions and were completely asymptomatic. Silent NC cases did not correlate with the exposure factors tested but showed family aggregation and higher rates of positive serology. Thus, NC prevalence may be higher than currently considered and host-related factors appear to be involved in infection and pathogenesis.

© 2003 S. Karger AG, Basel


References

  1. Sciutto E, Fragoso G, Fleury A, Laclette JP, Sotelo J, Aluja A, Vargas L, Larralde C: Taenia solium disease in humans and pigs: An ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensions. Microbes Infect 2000;2:1875–1890.
  2. Medina MT, Rosas E, Rubio-Donnadieu F, Sotelo J: Neurocysticercosis as the main cause of late-onset epilepsy in Mexico. Arch Intern Med 1990;150:325–327.
  3. Torres L: Neurocysticercosis and epilepsy in Peru. Clin Neurol Neurosurg 1992;94:53–54.
  4. Del Brutto OH, Sotelo J, Román GC: Neurocysticercosis. A Clinical Handbook. Exton, Swets & Zeitlinger, 1998.
  5. Flisser A, Woodhouse E, Larralde C: The epidemiology of human cysticercosis in Mexico; in Palacios J, Rodriguez-Carvajal J, Taveras JM (eds): Cysticercosis of the Central Nervous System. Springfield, Thomas Publisher, 1983, pp 7–17.
  6. Diaz-Camacho SP, Candil-Ruiz A, Suate-Peraza V: Epidemiologic study and control of Taenia solium infection with praziquantel in a rural village of Mexico. Am J Trop Med Hyg 1991;45:522–531.
  7. Sarti E, Schantz PM, Plancarte A, Wilson M, Gutierrez IO, Lopez AS, Roberts J, Flisser A: Prevalence and risk factors for Taenia solium taeniasis and cysticercosis in humans and pigs in a village in Morelos, Mexico. Am J Trop Med Hyg 1992;46:677–685.
  8. Sarti E, Schantz PM, Plancarte A, Wilson M, Gutierrez IO, Lopez AS, Roberts J, Flisser A: Epidemiological investigation of Taenia solium taeniasis and cysticercosis in a rural village of Michoacán state, México. Trans R Soc Trop Med Hyg 1994;88:49–52.
  9. Larralde C, Padilla A, Hernandez M, Govezensky T, Sciutto E, Gutierrez G, Tapia-Conyer R, Salvatierra B, Sepulveda J: Seroepidemiology of cysticercosis in Mexico. Salud Pública Méx 1992;34:197–210.
  10. Acuna-Soto R, Maguire JH, Wirth DF: Gender distribution in asymptomatic and invasive amebiasis. Am J Gastroenterol 2000;95:1277–1283.
  11. Baird JK: Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum. Ann Trop Med Parasitol 1998;92:367–390.
  12. Abel L, Dessein AJ: The impact of host genetics on susceptibility to human infectious diseases. Curr Opin Immunol 1997;9:509–516.
  13. Fragoso G, Lamoyi E, Mellor A, Lomelí C, Govezensky T, Sciutto E: Genetic control of susceptibility and resistance to Taenia crassiceps cysticercosis. Parasitology 1996;112:119–124.
  14. Fragoso G, Lamoyi E, Mellor A, Lomelí C, Hernández M, Sciutto E: Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice. Infect Immun 1998;66:760–764.
  15. Larralde C, Morales J, Terrazas I, Govezensky T, Romano MC: Sex hormone changes induced by the parasite lead to feminization of the male host in murine Taenia crassiceps cysticercosis. J Steroid Biochem Mol Biol 1995;52:575–580.
  16. Huerta M, Sciutto E, Garcia G, Villalobos N, Hernandez M, Fragoso G, Diaz J, Diaz A, Ramirez R, Luna S, Garcia J, Aguilar E, Espinoza S, Castilla G, Bobadilla JR, Avila R, Jose MV, Larralde C, de Aluja AS: Vaccination against Taenia solium cysticercosis in underfed rustic pigs of Mexico: Roles of age, genetic background and antibody response. Vet Parasitol 2000;90:209–219.
  17. Del Bruto OH, Granados G, Talamas O, Sotelo J, Gorodezky C: Genetic patterns of the HLA system: HLA A, B, C, DR, and DQ antigens in Mexican patients with parenchymal brain cysticercosis. Hum Biol 1991;63:85–93.
  18. Del Brutto OH, Garcia E, Talamas O, Sotelo J: Sex-related severity of inflammation in parenchymal brain cysticercosis. Arch Intern Med 1988;148:544–546.
  19. Ramos-Kuri M, Montoya RM, Padilla A, Govezensky T, Diaz ML, Sciutto E, Sotelo J, Larralde C: Immunodiagnosis of neurocysticercosis. Disappointing performance of serology (enzyme-linked immunosorbent assay) in an unbiased sample of neurological patients. Arch Neurol 1992;49:633–636.
  20. Rabiela MT, Lombardo-Rivera L, Flores-Barroeta F: Cisticercosis cerebral: Estudio de 68 casos de autopsia. Patologia 1972;10:27–39.
  21. Perez-Tamayo R, Flores-Barroeta F: Datos generales de 2,202 autopsias. Prensa Méd Méx 1959;24:117–118.
  22. Albores-Saavedra J, Altamirano DM: Algunas consideraciones sobre 9,412 autopsias realizadas en el Hospital General de México. Gac Méd Méx 1971;102:193–203.
  23. Mazer S, Antoniuk A, Ditzel LF, Araujo JC: The computed tomographic spectrum of cerebral cysticercosis. Comput Radiol 1983;7:373–378.
  24. Minguetti G, Ferreira MV: Computed tomography in neurocysticercosis. J Neurol Neurosurg Psychiatry 1983;46:936–942.
  25. Sanchez AL, Lindback J, Schantz PM, Sone M, Sakai H, Medina MT, Ljungstrom I: A population-based, case-control study of Taenia solium taeniasis and cysticercosis. Ann Trop Med Parasitol 1999;93:247–258.
  26. Nash TE, Pretell J, Garcia HH: Calcified cysticerci provoke perilesional edema and seizures. Clin Infect Dis 2001;33:1649–1653.
  27. Rosas N, Sotelo J, Nieto D: ELISA in the diagnosis of neurocysticercosis. Arch Neurol 1986;43:353–356.
  28. Ridaura-Sanz C: Host response in childhood neurocysticercosis. Childs Nerv Syst 1987;3:206–207.
  29. Sotelo J, Del Brutto O: Therapy of neurocysticercosis. Childs Nerv Syst 1987;3:208–211.
  30. Lara-Aguilera R, Mendoza-Cruz JF, Martínez-Toledo JL, Macias-Sánchez R, Willms K, Altamirano-Rojas L, Santamaría-Llano A: Taenia solium taeniasis and neurocysticercosis in a Mexican rural family. Am J Trop Med Hyg 1992;46:85–88.
  31. Schantz P, Moore A, Muñoz J, Hartman B, Schaefer J, Aron A, Persaud D, Sarti E, Wilson M, Flisser A: Neurocysticercosis in an orthodox Jewish community in New York city. N Engl J Med 1992;327:692–695.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: March 13, 2003
Issue release date: March – April

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: https://www.karger.com/NED


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