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Clinical and Laboratory Investigations

Porphyria cutanea tarda, C282Y, H63D and S65C HFE Gene Mutations and Hepatitis C Infection: A Study from Southern France

Chiavérini C.a · Halimi G.b · Ouzan D.c · Halfon P.b · Ortonne J.-P.a · Lacour J.-P.a

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aDepartment of Dermatology, Archet-2 Hospital, Nice, bLaboratory of Biochemistry, La Conception Hospital, Marseille, and cArnault Tzanck Institute, St-Laurent-du-Var, France

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Dermatology 2003;206:212–216

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: April 15, 2002
Accepted: August 14, 2002
Published online: April 17, 2003
Issue release date: 2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: To evaluate the role of genetic factors in the pathogenesis of porphyria cutanea tarda (PCT) and their association with chronic hepatitis C. Objective: To investigate the relations between hemochromatosis gene (HFE) mutations and PCT in the south of France and their links with chronic hepatitis C virus (HCV) infection. Methods: The genotype for the C282Y, H63D and S65C mutations of HFE was determined in 33 patients with PCT, 46 patients with HCV infection but without PCT and 58 controls. Iron status and HCV, HBV and HIV serologies were studied in all patients. Results: A statistically significant increase in the C282Y mutation was found in PCT patients. No difference was found for H63D or S65C mutations. The prevalence of HCV infection was higher in PCT patients than controls. Conclusions: C282Y mutations and HCV infection but not H63D or S65C mutations are PCT-triggering or associated factors in the south of France.

© 2003 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: April 15, 2002
Accepted: August 14, 2002
Published online: April 17, 2003
Issue release date: 2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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