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Original Paper

Digoxin-Like Immunoreactive Substance in Nonoliguric Hyperkalemia of the Premature Infant

Mildenberger E.a · Oels K.a · Bauer K.a · Paul M.b · Versmold H.T.a

Author affiliations

Departments of aPediatrics and bClinical Pharmacology, Universitätsklinikum Benjamin Franklin, Berlin, Germany

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Biol Neonate 2003;83:182–187

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 18, 2002
Published online: April 03, 2003
Issue release date: April 2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 18, 2002
Published online: April 03, 2003
Issue release date: April 2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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