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Original Paper

Involvement of IL-18 and Soluble Fas in Patients with Postoperative Hepatic Failure

Nakae H.a · Zheng Y.-J.a · Wada H.a · Tajimi K.a · Endo S.b

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aDepartment of Emergency and Critical Care Medicine, Akita University School of Medicine, Akita, and bDepartment of Critical Care Medicine, Iwate University School of Medicine, Morioka, Japan

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Eur Surg Res 2003;35:61–66

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 29, 2002
Accepted: August 01, 2002
Published online: April 17, 2003
Issue release date: March – April

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

We measured the levels of tumor necrosis factor alpha (TNF-α), interleukins (IL)-6 and -18, and soluble Fas (sFas) in 11 patients with postoperative hepatic failure and assessed whether IL-18-mediated apoptosis is involved in the onset of liver dysfunction. The serum TNF-α, IL-18, and sFas levels were significantly higher in patients with sepsis as a complication than in those without sepsis. The TNF-α and IL-18 levels were significantly higher in nonsurvivors than in survivors. Significant correlations were observed between TNF-α and IL-6, between TNF-α and IL-18, and between TNF-α and sFas levels. These results showed that Fas-mediated hepatocyte apoptosis functions as an important mechanism responsible for the onset of postoperative hepatic failure in humans. They especially suggested that IL-18 and TNF-α function both as apoptosis-promoting factors and as apoptosis-inhibiting factors, depending on the conditions to which hepatocytes are subjected.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 29, 2002
Accepted: August 01, 2002
Published online: April 17, 2003
Issue release date: March – April

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


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