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Original Paper

Serial Changes in Static and Dynamic Cerebral Autoregulation after Acute Ischaemic Stroke

Dawson S.L.a · Panerai R.B.b · Potter J.F.a

Author affiliations

aUniversity Division of Medicine for the Elderly, Leicester Warwick Medical School and bDepartment of Medical Physics, University of Leicester, Leicester, UK

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Cerebrovasc Dis 2003;16:69–75

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 27, 2002
Accepted: October 01, 2002
Published online: May 16, 2003
Issue release date: May 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

Background: The longitudinal changes in static and dynamic cerebral autoregulation (CA) following acute ischaemic stroke are unknown and were assessed in this study. Methods: Fifty-four ischaemic stroke patients were studied within 96 h of ischaemic stroke and again 7–14 days later, using transcranial Doppler techniques to measure CA. Results were compared to an age-, sex- and blood pressure (BP)-matched control group. Static BP pressor stimulus was produced by thigh cuff inflation and dynamic stimulus by rapid thigh cuff release. Results: Dynamic, but not static, CA was globally impaired at initial (mean dynamic CA index 3.9 ± 3.1 vs. 6.2 ± 2.3, p < 0.005) and follow-up studies (dynamic CA 3.9 ± 2.8 vs. 6.2 ± 2.3, p < 0.01) in stroke patients compared to controls. Static CA was similar in stroke patients and controls and was unchanged during follow-up. Conclusions: Dynamic, but not static, CA is impaired after acute ischaemic stroke and remains abnormal for at least 1–2 weeks post ictus. These changes are present in both the affected and non-affected hemispheres and are unrelated to previous antihypertensive treatment, baseline BP levels or BP changes after stroke, age or stroke type.

© 2003 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 27, 2002
Accepted: October 01, 2002
Published online: May 16, 2003
Issue release date: May 2003

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED


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