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Original Paper

Prognostic Implication of Microvascular Invasion in Biochemical Failure in Patients Treated with Radical Prostatectomy

Ito K.a · Nakashima J.a · Mukai M.b · Asakura H.a · Ohigashi T.a · Saito S.a · Tachibana M.a · Hata J.-i.b · Murai M.a

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Departments of aUrology and bPathology, School of Medicine, Keio University, Tokyo, Japan

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Urol Int 2003;70:297–302

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 22, 2001
Accepted: August 29, 2002
Published online: May 14, 2003
Issue release date: May 2003

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN

Abstract

Introduction: Micrometastasis before radical prostatectomy (RP) is considered to be related to the biochemical failure after surgery in patients with prostate cancer. To predict the biochemical failure, we evaluated microvascular (lymphatic/vascular) invasion and other pathological findings as prognostic factors for biochemical failure after RP. Materials and Methods: Eighty-two men who underwent RPs and received neither preoperative nor postoperative adjuvant therapy were analyzed. Pathological findings of each patient were carefully reviewed to determine pathological factors predicting biochemical failure. The influence of pathological findings on the biochemical failure was evaluated. Results: The overall biochemically assessed disease-free survival rate was 55.7% at 3 years. By univariate analysis, Gleason sum, capsular penetration, and microvascular invasion were significantly associated with the rate of biochemical failure. Microvascular invasion was strongly correlated with Gleason sum, capsular penetration, surgical margin, perineural invasion, and pathological stage. By multivariate analysis, Gleason sum, capsular penetration, and microvascular invasion were independent predictors of biochemical failure. Conclusion: This study suggests that in addition to Gleason grade and capsular penetration, microvascular invasion is one of independent prognostic factors in patients with prostate cancer treated with RPs.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 22, 2001
Accepted: August 29, 2002
Published online: May 14, 2003
Issue release date: May 2003

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN


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