Neuropsychobiology

Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Diffusion Tensor Magnetic Resonance Imaging of Disruption of Regional White Matter in Schizophrenia

Minami T.a · Nobuhara K.a · Okugawa G.a · Takase K.a · Yoshida T.a · Sawada S.b · Ha-Kawa S.b · Ikeda K.b · Kinoshita T.a

Author affiliations

Departments of aNeuropsychiatry and bRadiology, Kansai Medical University, Osaka, Japan

Keywords: Diffusion tensor imagingWhite matterSchizophreniaAnisotropy

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Neuropsychobiology 2003;47:141–145
https://doi.org/10.1159/000070583

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: May 21, 2003
Issue release date: May 2003

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia.

© 2003 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: May 21, 2003
Issue release date: May 2003

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

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2003, Vol.47, No. 3

May 2003

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