Biological Psychology/Pharmacopsychology. Editor: P. Netter (Giessen) / Original Paper
The Combined Effects of Apolipoprotein E Polymorphism and Low-Density Lipoprotein Cholesterol on Cognitive Performance in Young AdultsPuttonen S.a · Elovainio M.a · Kivimäki M.a · Lehtimäki T.b · Keltikangas-Järvinen L.a
aDepartment of Psychology, University of Helsinki, Helsinki, bLaboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, University Hospital of Tampere, and Tampere University Medical School, Department of Clinical Chemistry, Tampere, Finland
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
This study examined the relations of apolipoprotein E (ApoE) genotype and the low-density lipoprotein (LDL) cholesterol level to cognitive performance of 57 randomly selected healthy young adults. From the ongoing population-based study of Cardiovascular Risk in Young Finns, 25 men and 32 women were ApoE genotyped and participated in mental arithmetic and reaction time tasks. In contrast to findings obtained from studies with elderly subjects, ApoE4 polymorphism was associated with better cognitive performance. In addition, LDL cholesterol moderated this association. In the ApoE4 genotype group, low LDL cholesterol was associated with good performance in the mental arithmetic test, whereas for those without ApoE4 genotype, low LDL cholesterol was associated with poor performance. Performance in the reaction time task did not differ between the ApoE groups. In conclusion, assessment of the influence of ApoE on cognitive performance may require taking additional physiological factors, such as the level of cholesterol, into account.
© 2003 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.