Neonatology
Original Paper
Sequential Postnatal Changes in Erythrocyte Glutathione and Sulfhydryl Content: A Possible Adaptational Response to the Extrauterine EnvironmentJean-Baptiste D. · Rudolph N.SUNY Downstate Medical Center and Kings County Hospital Center, Department of Pediatrics, Brooklyn, New York, N.Y., USA
Keywords: NeonateErythrocytesGlutathione |
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Article / Publication Details
Received: February 06, 2003
Published online: August 15, 2003
Issue release date: August 2003
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Glutathione is a key factor in intracellular antioxidant defense mechanisms. We postulated that it might modulate the adaptational response of the fetus to a higher oxygen environment after birth. Therefore, we determined total glutathione (GSH + GSSG) and non-protein sulfhydryl (–SH) content in cord blood RBC hemolysates, and sequential values in blood from the same infants for up to 72 h after birth. We noted a consistent rapid decline in total glutathione content by 24 h in both term (–18%) and preterm (–24%) infants, with subsequent stabilization of levels in term infants. However, erythrocyte (–SH) content (measured only in term babies) remained stable and unchanged from levels in cord blood, indicating the presence of (–SH) in one or more other moieties in addition to GSH. We speculate on the possibility of a role for GSH as a (–SH) donor in modulating postnatal fetal adaptation.
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Article / Publication Details
Received: February 06, 2003
Published online: August 15, 2003
Issue release date: August 2003
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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