Neonatology

Original Paper

Hyaluronan in the Human Neonatal Lung: Association with Gestational Age and Other Perinatal Factors

Johnsson H.a · Eriksson L.b · Gerdin B.c · Hällgren R.d · Sedin G.a

Author affiliations

Departments of aWomen’s and Children’s Health, bGenetics and Pathology, cSurgery and dRheumatology, Uppsala University, Uppsala, Sweden

Keywords: Extravascular lung waterFetal developmentHyaluronanLung developmentLung diseaseNeonatal lung diseaseNewborn infantPostnatal development

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Biol Neonate 2003;84:194–201
https://doi.org/10.1159/000072302

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 24, 2003
Issue release date: October 2003

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

The aim of this study was to determine the influence of gestational age at birth, postnatal age, specific complications and methods of treatment on the lung hyaluronan concentration in infants. Lung samples and clinical records from 117 infants who died 0–228 days (32 weeks) after preterm or term birth were studied. The lung hyaluronan concentration at death was most strongly associated with the gestational age at birth, an association best described by an exponential function with a negative power coefficient. After adjustments for gestational age, the lung hyaluronan concentration also correlated significantly with birth weight, weight at death, the wet-to-dry lung weight ratio and specific staining for hyaluronan in the pleura. Intrauterine infection was also associated with a significantly higher lung hyaluronan concentration.

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 24, 2003
Issue release date: October 2003

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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2003, Vol.84, No. 3

October 2003

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