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Original Paper

Family-Based Association Analysis with Tightly Linked Markers

Knapp M. · Becker T.

Author affiliations

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany

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Hum Hered 2003;56:2–9

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 2003
Accepted: June 03, 2003
Published online: November 14, 2003
Issue release date: November 2003

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE

Abstract

Refining genomic regions which have been identified by linkage analysis to contain a disease susceptibility locus has proven to be a challenging task. Detecting association between the disease and a genetic marker can significantly narrow down the candidate region. Since an adequate sample of families is already available from the genome scan, family-based association tests may be used to search for association. The use of haplotypes consisting of tightly linked markers can be more powerful for detecting association than the use of individual markers. An extension of the transmission/disequilibrium test to allow the simultaneous analysis of more than one marker locus is complicated by ambiguity of phase in some families of the sample. The present paper shows that a recently proposed method for the analysis of nuclear families with a single affected child can be viewed as a special application of a more general principle. This observation justifies several modifications, potentially increasing the power, as well as an extension of the method to allow the analysis of general nuclear families. Finally, the problem of missing parental genotypes is discussed.

© 2003 S. Karger AG, Basel


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    External Resources
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    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 2003
Accepted: June 03, 2003
Published online: November 14, 2003
Issue release date: November 2003

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE


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