Hormone Research in Paediatrics
Original Paper
Skeletal Disproportion in Children with Chronic Renal DiseaseQayyum N.a · Alcocer L.a · Maxwell H.b · Beattie T.J.b · Murphy A.V.b · Ramage I.J.b · Ahmed S.F.aaBone and Endocrine Research Group, and bThe Renal Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: July 01, 2003
Accepted: July 18, 2003
Published online: November 19, 2003
Issue release date: 2003
Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Objectives: To assess stature and skeletal disproportion in children with chronic renal disease. Methods: Cross-sectional study of height (HT), sitting height (SH), subischial leg length (SILL), sitting height/height ratio (SH:HT) and disproportion score (SH SDS minus SILL SDS) in 56 children (M:35) with median age 11.4 years (range 4.5,18.7) with chronic renal disease. Results: There were 19 children with chronic renal insufficiency, 6 receiving peritoneal dialysis and 31 after renal transplant. The median HTSDS for the whole group was –1.21 (–2.8, 0.35). The median SH:HT ratio in non-transplanted children and renal transplant were 0.51 (0.49, 0.53) and 0.50 (0.48, 0.53), respectively (p = 0.02). The median disproportion score of the whole group was –3.2 (–4.8, –1.8). There was a significant correlation between disproportion score and SH:HT (r = 0.5, p = 0.005). SH:HT ratio was negatively related to duration of illness (r = 0.4, p = 0.005). Conclusion: Children with chronic renal disease have significant body disproportion and this may be due to a disproportionately greater effect of disease and treatment on spinal growth.
© 2003 S. Karger AG, Basel
Related Articles:
References
-
Schaefer F, Mehls O: Growth failure in chronic renal disorders; in Kelnar CJH, Savage MO, Stirling HF, Saenger P (eds): Growth Disorders. London, Chapman & Hall, 1998.
- Hokken-Koelega ACS, Stijnen T, De Muinck Keizer-Scrama SMPF, Wit JM, Wolff ED, De Jong MCJW, Donckerwolke RA, Abbad NCB, Bot A, Blum WF, Drop SLS: Placebo-controlled, double-blind cross-over trial of growth hormone treatment in prepubertal children with chronic renal failure. Lancet 1991;338:585–590.
- Maxwell H, Rees L: Randomised controlled trial of recombinant growth hormone in prepubertal and pubertal renal transplant recipients. Arch Dis Child 1998;79:481–487.
- Haffner D, Schaefer F, Nissel R, Wuhl E, Tonshoff B, Mehls O: Effect of growth hormone treatment on the adult height of children with chronic renal failure. N Engl J Med 2000;343:923–930.
- Tonshoff B, Mehls O: Factors affecting growth and strategies for treatment in children after renal transplantation. Pediatr Transplant 1997;1:176–182.
- Fine RN: Growth post renal-transplantation in children: Lessons from the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant 1997;1:85–89.
-
Tanner JM, Whitehouse RH: Standards for sitting height and sub-ischial leg length from birth to maturity: British children 1978. Ware, Castlemead Publications, 1979.
-
Styne DM: The physiology of puberty; in Brook CGD (ed): Clinical Paediatric Endocrinology, ed 4. Oxford, Blackwell Science, 1995.
- Freeman JV, Cole TJ, Chinn S, Jones PRM, White EM, Preece MA: Cross-sectional stature and weight reference curves for the UK, 1990. Arch Dis Child 1995;73:17–24.
- Davies HA, Didcock E, Didi M, Ogilvy-Stuart A, Wales JKH, Shalet SM: Disproportionate short stature after cranial irradiation and combination chemotherapy for leukaemia. Arch Dis Child 1994;70:472–475.
-
Albanese A, Stanhope R: Predictive factors in the determination of final height in boys with constitutional delay of growth and puberty. Arch Dis Child 1995;126:545–550.
- Ahmed SF, Wardhaugh B, Wallace WHB, Kelnar CJH: An anthropometric study of children during treatment for acute lymphoblastic leukaemia. Horm Res 1997;48:178–183.
-
Filosa A, Di Maio S, Baron I, Esposito G, Galati MG: Final height and body disproportion in thalassaemic boys and girls with spontaneous or induced puberty. Acta Paediatr 2000;89:1295–1301.
- Van Diemen-Steenvoorde R, Donckerwolcke RA, Brackel H, Wolff E, De Jong MC: Growth and sexual maturation in children after kidney transplantation. J Pediatr 1987;110:351–356.
- Ziolkowska H, Panczyk-Tomaszewska M, Majkowska Z et al: Imaging of bone in the diagnostics of renal osteodystrophy in children with chronic renal failure. Med Sci Monit 2001;7:1034–1042.
-
Mushtaq T, Ahmed SF: The impact of corticosteroids on growth and bone health. Arch Dis Child, in press.
- Sprague SM: Mechanism of transplantation-associated bone loss. Pediatr Nephrol 2000;14:650–653.
- Lems WF, Jahangier ZN, Raymakers JA, Jacobs JW, Bijlsma JW: Methods to score vertebral deformities in patients with rheumatoid arthritis. Br J Rheumatol 1997;36:220–224.
- Ellis EN, Floyd-Gimon DM, Berry PL, Wells TG, Seibert J, Belsha C: Risk factors for bone mineral density loss in pediatric renal transplant patients. Pediatr Transplant 2000;4:146–150.
- Schlosberg M, Movsowitz C, Epstein S, Ismail F, Fallon MD, Thomas S: The effect of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat. Endocrinology 1989;124:2179–2184.
- Arolki A, Tarantino A, Montagnino F, Cesana B, Cocucci C, Pontinelli C: Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: A prospective study. Transplantation 1997;63:380–386.
-
Hokken-Koelega ACS, Saenger P, Cappa M, Greggio N: Unresolved problems concerning optimal therapy of puberty in children with chronic renal diseases. J Pediatr Endocrinol Metab 2001;14:945–952.
- Maxwell, H, Haffner D, Rees L: Catch-up growth occurs after renal transplantation in children of pubertal age. J Pediatr 1998;133:435–440.
Article / Publication Details
Received: July 01, 2003
Accepted: July 18, 2003
Published online: November 19, 2003
Issue release date: 2003
Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
