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Clinical and Laboratory Investigation

Lack of Association between the Promoter Polymorphisms at Positions –308 and –238 of the Tumor Necrosis Factor Alpha Gene and Psoriasis vulgaris in Japanese Patients

Tsunemi Y.a · Nishibu A.b · Saeki H.a · Oyama N.b · Nakamura K.b · Kishimoto M.a · Mitsui H.a · Tada Y.a · Torii H.a · Komine M.a · Asahina A.a · Kaneko F.b · Tamaki K.a

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aDepartment of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, and bDepartment of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan

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Dermatology 2003;207:371–374

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: February 18, 2003
Accepted: June 13, 2003
Published online: January 29, 2004
Issue release date: 2003

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Psoriasis features an increased level and activity of tumor necrosis factor α (TNF-α). The TNF-α gene has single nucleotide polymorphisms (SNPs) at positions –308 (–308G>A) and –238 (–238G>A) in the promoter region, and the –238G>A SNP has been reported to be associated with psoriasis vulgaris (PV) and psoriatic arthritis in Caucasians. Objective: To examine whether these SNPs are associated with susceptibility to PV in Japanese patients, we investigated the genotype and allele frequencies at each SNP in Japanese PV patients and in controls. Methods: We examined 163 PV patients and 96 healthy individuals. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Results: No significant association between the genotypes or alleles of these SNPs and susceptibility to PV was observed. Conclusion: These SNPs themselves are not associated with susceptibility to PV in the Japanese.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: February 18, 2003
Accepted: June 13, 2003
Published online: January 29, 2004
Issue release date: 2003

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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