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Review

Cyclin-Dependent Kinase 5 in Amyotrophic Lateral Sclerosis

Nguyen M.D.a · Julien J.-P.b

Author affiliations

aDepartment of Pathology, Harvard Medical School, Boston, Mass., USA; bCHUL Research Center, Laval University, Sainte-Foy, Que., Canada

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Neurosignals 2003;12:215–220

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: April 10, 2003
Accepted: May 13, 2003
Published online: December 18, 2003
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: https://www.karger.com/NSG

Abstract

Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering the phosphorylation state of cytosolic and cytoskeletal proteins and, possibly, through the induction of cell cycle regulators. The present paper reviews these findings and proposes new perspectives to decipher the mechanisms of neurodegeneration in amyotrophic lateral sclerosis induced by Cdk5.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Received: April 10, 2003
Accepted: May 13, 2003
Published online: December 18, 2003
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: https://www.karger.com/NSG


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