Original Article · Originalarbeit
Wirksamkeit von Arnica bei Varizenoperation: Ergebnisse einer randomisierten, doppelblinden, Placebo-kontrollierten Pilot-StudieWolf M.a · Tamaschke C.b · Mayer W.c · Heger M.d
aPraxis für Homöopathie, Berlin-Karow; bPraxis für Gefässerkrankungen, Berlin-Buch; cClinical Study Monitoring, Walldorf-Heidelberg; dForschungszentrum HomInt, Karlsruhe, Deutschland
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Efficacy of Arnica in Varicose Vein Surgery: Results of a Randomized, Double-Blind, Placebo-Controlled Pilot Trial Introduction: In homeopathy Arnica is widely used as a woundhealing medication and for the treatment of hematomas. Objective: In this pilot study the efficacy and safety of Arnica D12 in patients following varicose vein surgery were investigated. Design: Prospective, randomized, double-blind, placebo-controlled pilot trial according to ICH GCP guidelines. Setting: The study was conducted by a surgeon at the Angiosurgical Clinic, Berlin- Buch. Intervention: After randomized allocation, 60 patients received either Arnica D12 or placebo. Start of medication occurred the evening before operation with 5 globules. On the operation day one preoperative and hourly postoperative dosages after awakening were given. On days 2–14 of the study 5 globules 3 times a day were given. Outcome Criteria: Surface (in cm² and using a three-point verbal rating scale) and intensity of hematomas induced by operation, complications of wound healing, and intensity of pain (five-point verbal rating scale) as well as efficacy and safety of the study medication were assessed. Results: Hematoma surface was reduced (from day 7 to day 14) under Arnica by 75.5% and under placebo by 71.5% (p = 0.4726). The comparison of hematoma surface (small, medium, large) using the verbal rating scale yielded a value of p = 0.1260. Pain score decreased by 1.0 ± 2.2 points under Arnica and 0.3 ± 0.8 points under placebo (p = 0.1977). Remission or improvement of pain was observed in 43.3% of patients in the Arnica group and in 27.6% of patients in the placebo group. Tolerability was rated as very good in all cases. Conclusion: The results of this pilot study showed a trend towards a beneficial effect of Arnica D12 with regard to reduction of hematoma and pain during the postoperative course. For a statistically significant proof of efficacy of Arnica D12 in patients following varicose vein surgery a larger sample size is necessary.
© 2003 S. Karger GmbH, Freiburg
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.