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World Congresses of Gastroenterology, Vienna, September 1998
Symposium: Update on Hepatic Fibrosis
Guest Editor: Detlef Schuppan, Erlangen

Fibrosis and Altered Matrix Degradation

Arthur M.J.P.

Author affiliations

University of Southampton, UK

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Digestion 1998;59:376–380

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Article / Publication Details

Published online: August 03, 1998
Issue release date: July – August

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


First-Page Preview
Abstract of World Congresses of Gastroenterology, Vienna, September 1998<br>Symposium: Update on Hepatic Fibrosis<br>Guest Editor: Detlef Schuppan, Erlangen

References

  1. Cawston T: Matrix metalloproteinases and TIMPs: Properties and implications for the rheumatic diseases. Mol Med Today 1998;4:130–137.
    External Resources
  2. Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJP: Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci 1995;89:75–81.
    External Resources
  3. Iredale JP, Benyon RC, Arthur MJP, Ferris WF, Alcolado R, Winwood PJ, Clark N, Murphy G: Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 1996;24:176–184.
  4. Vyas SK, Leyland H, Gentry J, Arthur MJP: Transin (stromelysin) is expressed in early rat lipocyte primary culture. Gastroenterology 1995;109:889–898.
  5. Arthur MJP, Friedman SL, Roll FJ, Bissell DM: Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 1989;84:1076–1085.
  6. Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL: Secretion of 72-kDa type IV collagenase/gelatinase by cultured human lipocytes: Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992;287:701–707.
  7. Hovell CJ, Benyon RC, Baker JE, Arthur MJP: Membrane-type matrix metalloproteinase is produced by hepatic stellate cells. Hepatology 1995;22(suppl):369A.
  8. Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJP, Arthur MJP: Kupffer cell-derived 95-kDa type IV collagenase/gelatinase B: Characterisation and expression in cultured cells. Hepatology 1995;22:304–315.
  9. Fujiwara K, Sakai T, Oda T, Igarashi S: The presence of collagenase in Kupffer cells of the rat liver. Biochem Biophys Res Commun 1973;54:531–537.
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  10. Theret N, Musso O, Lhelgoualch A, Clement B: Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol 1997;150:51–58.
  11. Herbst H, Heinrichs O, Schuppan D, Milani S, Stein H: Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver. Virchows Arch B Cell Pathol 1991;60:295–300.
  12. Milani S, Herbst H, Schuppan D, Grappone SC, Pellegrini G, Pinzani M, Casini A, Calabro A, Ciancio G, Stefanini F, Burroughs AK, Surrenti C: Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994;144:528–537.
  13. Takahara T, Furui K, Funaki J, Nakayama Y, Itoh H, Miyabayashi C, Sato H, Seiki M, Ooshima A, Watanabe A: Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. Hepatology 1995;21:787–795.
  14. Benyon RC, Hovell CJ, Arthur MJP: Gelatinase A (72-kDa type IV collagenase) is an autocrine proliferation factor for rat hepatic stellate cells. Hepatology 1997;26:186A.
  15. Perez-Tamayo R, Montfort I, Gonzalez E: Collagenolytic activity in experimental cirrhosis of the liver. Exp Mol Pathol 1987;47:300–308.
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  16. Maruyama K, Feinman L, Okazaki I, Lieber CS: Direct measurement of neutral collagenase activity in homogenates from baboon and human liver. Biochim Biophys Acta 1981;658:121–131.
  17. Maruyama K, Feinman L, Fainsilber Z, Nakano M, Okazaki I, Lieber CS: Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis. Life Sci 1982;30:1379–1384.
  18. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJP: Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinase-1 (TIMP-1): Implications for regulation of matrix degradation in liver. J Clin Invest 1992;90:282–287.
  19. Kordula T, Guttgemann I, Rosejohn S, Roeb E, Osthues A, Tschesche H, Koj A, Heinrich PC, Graeve L: Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2) – Up-regulation by interleukin-6 and transforming growth factor-beta 1. FEBS Lett 1992;313:143–147.
  20. Roeb E, Graeve L, Hoffmann R, Decker K, Edwards DR, Heinrich PC: Regulation of tissue inhibitor of metalloproteinase-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. Hepatology 1993;18:1437–1442.
  21. Roeb E, Graeve L, Mullberg J, Matern S, Rosejohn S: TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes. FEBS Lett 1994;349:45–49.
  22. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP: Expression of tissue inhibitor of metalloproteinase-1 and -2 in increased in fibrotic human liver. Gastroenterology 1996;110:821–831.
  23. Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO, Neuhaus P, Gressner AM, Schuppan D: Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 1997;150:1647–1659.
  24. Iredale JP, Northrop M, Vincent K, Mann DA, Arthur MJP: Possible role of apoptosis in regulating activated stellate cell numbers during liver injury. J Hepatol 1997;26:132.
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  25. Bahr MJ, Fowler AV, Arthur MJP, Mann DA: Cell type-specific regulation of the tissue inhibitor of metalloproteinase (TIMP)-1 gene promoter in hepatic stellate cells. J Hepatol 1997;26(suppl 1):66.
  26. Mann DA, Bahr MJ, Vincent K, Arthur MJP: Induction of AP-1 DNA binding proteins during culture activation of hepatic stellate cells. Hepatology 1997;26:371A.

Article / Publication Details

Published online: August 03, 1998
Issue release date: July – August

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


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