Transient Decrease in the CD45RA Expression on T Lymphocytes in Neonates with Fetal DistressMizobe N.a,d · Sugita K.a · Tezuka T.a · Sakamoto M.b · Fukada Y.c · Hoshi K.c · Nakazawa S.a
Departments of aPediatrics, bClinical and Laboratory Medicine, and cObstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, and dDivision of Neonatology, Perinatal Center, YamanashiPrefectural Central Hospital, Yamanashi, Japan
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
To determine the expression of CD45 isoforms on T lymphocytes in neonates with fetal distress and to evaluate its diagnostic accuracy, peripheral blood samples were examined in 53 neonates who were classified into one of three groups: group I: ‘control’ group (n = 23), group II: ‘mild distress’ group (n = 15), and group III: ‘moderate distress’ group (n = 15). The expression of CD3 (mean ± SD 24.2 ± 10.1%), CD4 (23.0 ± 5.7%), and CD45RA (27.3 ± 9.6%) on total lymphocytes and the expression of CD45RA on CD4+ T lymphocytes (13.7 ± 4.7%) in group III were significantly lower than in the other two groups 0–3 days after birth. Sensitivity and specificity of the CD45RA expression on CD4+ T lymphocytes for discrimination of group III were calculated as 0.79 and 1.0, respectively, when the cutoff value was 22.7%. The low CD3, CD4, and CD45RA expression returned to normal levels 10 days and more after birth. There were no differences in the CD8 and CD45RO expression between the groups. We conclude that CD4+ T lymphocytes from neonates with fetal distress show a transient decrease in the CD45RA expression without an increase in the CD45RO expression, and, therefore, analysis of the CD45 isoform expression is useful for laboratory evaluation of fetal distress.
© 2004 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.