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Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed

Seabury C.M. · Derr J.N.

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Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station TX (USA)

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Cytogenet Genome Res 102:85–88 (2003)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 25, 2003
Accepted: July 30, 2003
Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Susceptibility to scrapie is primarily controlled by polymorphisms in the ovine prion protein gene (PRNP). Here, we report a novel ovine exon three PRNP polymorphism (SNP G346C; P116), its association with the ovine ARQ allele (P116A136R154Q171), and two new genotypes (PARQ/ARR; PARQ/ARQ) for the St. Croix White (SCW) breed and a related composite (CMP) breed developed for meat production. The (P116) polymorphism occurs between the N-terminal cleavage site and the hydrophobic region of the ovine prion protein, a region which exhibits extreme conservation across mammalian taxa. The relatively high frequency (0.75) of resistant ARR alleles and the absence of ARQ alleles for the SCW ewes used as breeding stock for CMP resulted in significant genic differentiation (P = 0.0123; S.E. = 0.00113). Additionally, the majority of the SCW (66.7%) and CMP (65.4%) sampled possessed genotypes considered resistant or nearly resistant to scrapie and experimental BSE (bovine spongiform encephalopathy.   

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 25, 2003
Accepted: July 30, 2003
Published online: March 01, 2004
Issue release date: 2003

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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