Cytogenetic and Genome Research
Karyotypic relationships of horses and zebras: results of cross-species chromosome paintingYang F.a,b · Fu B.a · O’Brien P.C.M.a · Robinson T.J.c · Ryder O.A.d · Ferguson-Smith M.A.aaCentre for Veterinary Science, University of Cambridge, Cambridge (UK); bKey Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan (PR China); cEvolutionary Genomics Group, Department of Zoology, University of Stellenbosch, Stellenbosch (South Africa); dThe Zoological Society of San Diego, Centre for Reproduction of Endangered Species, San Diego, CA (USA)
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Cytogenet Genome Res 102:235–243 (2003)
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Article / Publication Details
First-Page Preview
Received: May 28, 2003
Accepted: August 05, 2003
Published online: March 01, 2004
Issue release date: 2003
Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
Complete sets of chromosome-specific painting probes, derived from flow-sorted chromosomes of human (HSA), Equus caballus (ECA) and Equus burchelli (EBU) were used to delineate conserved chromosomal segments between human and Equus burchelli, and among four equid species, E. przewalskii (EPR), E. caballus, E. burchelli and E. zebra hartmannae (EZH) by cross-species chromosome painting. Genome-wide comparative maps between these species have been established. Twenty-two human autosomal probes revealed 48 conserved segments in E. burchelli. The adjacent segment combinations HSA3/21, 7/16p, 16q/19q, 14/15, 12/22 and 4/8, presumed ancestral syntenies for all eutherian mammals, were also found conserved in E. burchelli. The comparative maps of equids allow for the unequivocal characterization of chromosomal rearrangements that differentiate the karyotypes of these equid species. The karyotypes of E. przewalskii and E. caballus differ by one Robertsonian translocation (ECA5 = EPR23 + EPR24); numerous Robertsonian translocations and tandem fusions and several inversions account for the karyotypic differences between the horses and zebras. Our results shed new light on the karyotypic evolution of Equidae.
© 2003 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Received: May 28, 2003
Accepted: August 05, 2003
Published online: March 01, 2004
Issue release date: 2003
Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
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