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Research Paper

Expression of Costimulatory Molecules (4-1BBL and Fas) and Major Histocompatibility Class I Chain-Related A (MICA) in Aortic Tissue with Takayasu’s Arteritis

Seko Y.a,c,d · Sugishita K.a · Sato O.b · Takagi A.b · Tada Y.e · Matsuo H.f · Yagita H.c · Okumura K.c · Nagai R.a

Author affiliations

aDepartment of Cardiovascular Medicine and bSecond Department of Surgery, Graduate School of Medicine, University of Tokyo, cDepartment of Immunology, School of Medicine, Juntendo University, and dInstitute for Adult Diseases, Asahi Life Foundation, Tokyo; eSecond Department of Surgery, Yamanashi Medical College, Yamanashi, and fDivision of Angiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan

Related Articles for ""

J Vasc Res 2004;41:84–90

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: October 09, 2003
Accepted: November 22, 2003
Published online: February 20, 2004
Issue release date: January – February

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: https://www.karger.com/JVR

Abstract

To further investigate the immunological mechanisms involved, we analyzed the expression of costimulatory molecules in aortic tissue and their counterpart molecules on infiltrating cells of patients with Takayasu’s arteritis. We also examined the expression of major histocompatibility complex (MHC) class I chain-related (MIC) A in aortic tissue, which is known to be induced by external stress, and its counterpart NKG2D receptors on infiltrating cells. Among these costimulatory molecules, strong expression of 4-1BBL and Fas was induced in the aortic tissue, and most of the infiltrating cells expressed 4-1BB and FasL, suggesting these pathways play critical roles in T-cell-mediated vascular injury. We also found that MICA was strongly induced in the aortic tissue and that at least part of the infiltrating cells expressed NKG2D receptors. Some infiltrating cells – but not vascular smooth muscle cells – seemed to have undergone apoptosis. Our findings strongly suggest that 4-1BB/4-1BBL and Fas/FasL pathways play important roles in vascular injury in Takayasu’s arteritis. We assume that γδ T cells infiltrated aortic tissue recognizing MICA, resulting in the induction of MHC antigens and costimulatory molecules, and then αβ T-cells infiltrated recognizing some auto-antigens presented by MHC antigens, leading to chronic inflammation.

© 2004 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: October 09, 2003
Accepted: November 22, 2003
Published online: February 20, 2004
Issue release date: January – February

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: https://www.karger.com/JVR


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